ArticleMolecular pain2014
Supraspinal characterization of the thermal grill illusion with fMRI.
Article in Molecular pain, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Reliability and Validity of a Novel, Portable Thermal Grill Illusion Apparatus Using Two Graphene Probes: An Initial Psychophysical Validation Study.European journal of pain (London, England) · 2026Observational
- Thermosensory predictive coding underpins an illusion of pain.Science advances · 2025Article
- A novel thermoelectric device integrated with a psychophysical paradigm to study pain processing in human subjects.Journal of neuroscience methods · 2023Article
- Thermal Grill Illusion in Chronic Lower Back Pain: A Case-Control Study.Journal of pain research · 2023Article
- Using electrodermal activity to validate multilevel pain stimulation in healthy volunteers evoked by thermal grills.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Addressing chronic persistent headaches after MTBI as a neuropathic pain state.The journal of headache and pain · 2020Review
- Thermal grill conditioning: Effect on contact heat evoked potentials.Scientific reports · 2017Article
- Diminished supraspinal pain modulation in patients with mild traumatic brain injury.Molecular pain · 2016Article
- Article
- No association of polymorphisms in the serotonin transporter gene with thermal pain sensation in healthy individuals.Molecular pain · 2014Article
- Article
- Pain-related white matter tract abnormalities in mild traumatic brain injury patients with persistent headache.Molecular painArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSimultaneous presentation of non-noxious warm (40°C) and cold (20°C) stimuli in an interlacing fashion results in a transient hot burning noxious sensation (matched at 46°C) known as the thermal grill (TG) illusion. Functional magnetic resonance imaging and psychophysical assessments were utilized to compare the supraspinal events related to the spatial summation effect of three TG presentations: 20°C/20°C (G2020), 20°C/40°C (G2040) and 40°C/40°C (G4040) with corresponding matched thermode stimuli: 20°C (P20), 46°C (P46) and 40°C (P40) and hot pain (HP) stimuli.
resultsFor G2040, the hot burning sensation was only noted during the initial off-line assessment. In comparison to P40, G4040 resulted in an equally enhanced response from all supraspinal regions associated with both pain sensory/discriminatory and noxious modulatory response. In comparison to P20, G2020 presentation resulted in a much earlier diminished/sedative response leading to a statistically significantly (P < 0.01) higher degree of deactivation in modulatory supraspinal areas activated by G4040. Granger Causality Analysis showed that while thalamic activation in HP may cast activation inference in all hot pain related somatosensory, affective and modulatory areas, similar activation in G2040 and G2020 resulted in deactivation inference in the corresponding areas.
conclusionsIn short, the transient TG sensation is caused by a dissociated state derived from non-noxious warm and cold spatial summation interaction. The observed central dissociated state may share some parallels in certain chronic neuropathic pain states.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.