ArticleJournal of thrombosis and haemostasis : JTH2014
Plasmin deficiency leads to fibrin accumulation and a compromised inflammatory response in the mouse brain.
Article in Journal of thrombosis and haemostasis : JTH, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- New Wine in an Old Bottle: tPA for Ischemic Stroke Management.Translational stroke research · 2025Article
- Spatiotemporal perturbations of the plasminogen activation system in a rat model of acute organophosphate intoxication.Acta neuropathologica communications · 2025Article
- Cerebrospinal Fluid Proteomic Profiles in Patients with Postherpetic Neuralgia.Journal of proteome research · 2023Article
- Effects of Thrombin on the Neurovascular Unit in Cerebral Ischemia.Cellular and molecular neurobiology · 2022Review
- The protective effect of early dietary fat consumption on Alzheimer's disease-related pathology and cognitive function in mice.Alzheimer's & dementia (New York, N. Y.) · 2021Article
- Using antifibrinolytics to tackle neuroinflammation.Neural regeneration research · 2020Review
- A critical role for plasminogen in inflammation.The Journal of experimental medicine · 2020Review
- Anticoagulants for Treatment of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2020Review
- Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines.Journal of neuroinflammation · 2019Article
- Dichotomous Role of Plasmin in Regulation of Macrophage Function after Acetaminophen Overdose.The American journal of pathology · 2019Article
- Plasminogen mediates communication between the peripheral and central immune systems during systemic immune challenge with lipopolysaccharide.Journal of neuroinflammation · 2019Article
- Epitope Mapping Immunoassay Analysis of the Interaction between β-Amyloid and Fibrinogen.International journal of molecular sciences · 2019Article
- Plasminflammation-An Emerging Pathway to Bradykinin Production.Frontiers in immunology · 2019Review
- Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer's disease.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Blood will out: vascular contributions to Alzheimer's disease.The Journal of clinical investigation · 2018Review
- Hydrogel-assisted neuroregeneration approaches towards brain injury therapy: A state-of-the-art review.Computational and structural biotechnology journal · 2018Review
- Neuro-Immune Hemostasis: Homeostasis and Diseases in the Central Nervous System.Frontiers in cellular neuroscience · 2018Review
- Clots Are Potent Triggers of Inflammatory Cell Gene Expression: Indications for Timely Fibrinolysis.Arteriosclerosis, thrombosis, and vascular biology · 2017Article
- Interactions of β-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer's disease.Current opinion in hematology · 2017Review
- Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundExcess fibrin in blood vessels is cleared by plasmin, the key proteolytic enzyme in fibrinolysis. Neurological disorders and head trauma can result in the disruption of the neurovasculature and the entry of fibrin and other blood components into the brain, which may contribute to further neurological dysfunction.
objectivesWhile chronic fibrin deposition is often implicated in neurological disorders, the pathological contributions attributable specifically to fibrin have been difficult to ascertain. An animal model that spontaneously acquires fibrin deposits could allow researchers to better understand the impact of fibrin in neurological disorders.
methodsBrains of plasminogen (plg)- and tissue plasminogen activator (tPA)-deficient mice were examined and characterized with regard to fibrin accumulation, vascular and neuronal health, and inflammation. Furthermore, the inflammatory response following intrahippocampal lipopolysaccharide (LPS) injection was compared between plg(-/-) and wild type (WT) mice. RESULTS AND
conclusionsBoth plg(-/-) and tPA(-/-) mice exhibited brain parenchymal fibrin deposits that appear to result from reduced neurovascular integrity. Markers of neuronal health and inflammation were not significantly affected by proximity to the vascular lesions. A compromised neuroinflammatory response was also observed in plg(-/-) compared to WT mice following intrahippocampal LPS injection. These results demonstrate that fibrin does not affect neuronal health in the absence of inflammation and suggest that plasmin may be necessary for a normal neuroinflammatory response in the mouse CNS.
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