ArticleExperimental and clinical psychopharmacology2014
Interactive association of dopamine receptor (DRD4) genotype and ADHD on alcohol expectancies in children.
Article in Experimental and clinical psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- DRD4 48 bp multiallelic variants as age-population-specific biomarkers in attention-deficit/hyperactivity disorder.Translational psychiatry · 2020Pooled it
- Risky decision-making in children with and without ADHD: A prospective study.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2018Article
- Impaired Social Decision-Making Mediates the Association Between ADHD and Social Problems.Journal of abnormal child psychology · 2016Article
- ADHD and Marijuana-Use Expectancies in Young Adulthood.Substance use & misuse · 2015Article
- ADHD, impulsivity and alcohol abuse: methods, results, and implications.Experimental and clinical psychopharmacology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Positive and negative alcohol expectancies (AEs) are beliefs about the consequences of alcohol use (e.g., happy, sad, lazy) and they predict patterns of adolescent and adult alcohol engagement in clinical and nonclinical samples. However, significantly less is known about predictors of AE in children, despite significant variability in AE early in and across development. To identify temporally ordered risk factors that precede AE, we evaluated the independent and interactive association of the functional 7-repeat polymorphism of the dopamine D4 receptor (DRD4) genotype and attention-deficit/hyperactivity disorder (ADHD) with respect to individual differences in positive-social, negative-arousal, sedated/impaired, and wild/crazy AE in school-age children (N = 149) prospectively followed from 6-9 to 8-13 years of age. Controlling for age, sex, and wave, DRD4 7+ carriers reported more wild/crazy AE, but DRD4 was unrelated to the remaining AE domains. ADHD symptoms independently predicted higher negative-arousal, sedated/impaired, and wild/crazy AE, but not positive-social. We also observed a significant interaction in which ADHD symptoms positively predicted wild/crazy AE only in youth with the 7-repeat DRD4 genotype; the same interaction marginally predicted sedated/impaired AE. No interactive effects were observed for the remaining AE domains. These preliminary results suggest that, among DRD4 youth, early ADHD symptoms predict that children will expect alcohol to have wild/crazy effects. We consider these results within a developmental framework to better understand pathways to and from youth alcohol problems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.