ArticleACS applied materials & interfaces2014
Electrochemically modulated nitric oxide (NO) releasing biomedical devices via copper(II)-Tri(2-pyridylmethyl)amine mediated reduction of nitrite.
Article in ACS applied materials & interfaces, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 68 citations in OpenAlex.
- Electroanalytical Methods to Establish the Role of Buffer and Electrolyte Components in Water Denitrification Using a Copper-Based Bioinspired Electrocatalyst.ACS measurement science au · 2026Article
- Sculpting Microbial Microenvironments: Spatiotemporal Control via Programmable Electrochemical Gradients.Journal of the American Chemical Society · 2026Review
- Regulation of nitric oxide generation and consumption.International journal of biological sciences · 2025Review
- Nitrite Reductases in Biomedicine: From Natural Enzymes to Artificial Mimics.Research (Washington, D.C.) · 2025Review
- Synthetically Reversible, Proton-Mediated Nitrite N-O Bond Cleavage at a Dicopper Site.Journal of the American Chemical Society · 2024Article
- Discussing the Terms Biomimetic and Bioinspired within Bioinorganic Chemistry.Inorganic chemistry · 2024Article
- A Review of Recent Advancements in Sensor-Integrated Medical Tools.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Elucidation of the Electrocatalytic Nitrite Reduction Mechanism by Bio-Inspired Copper Complexes.ACS catalysis · 2023Article
- Electrochemical Generation of Nitric Oxide for Medical Applications.Electrochemical science advances · 2022Article
- Nitric Oxide Release and Antibacterial Efficacy Analyses ofACS applied bio materials · 2022Article
- Mapping the DNA Damaging Effects of Polypyridyl Copper Complexes with DNA Electrochemical Biosensors.Molecules (Basel, Switzerland) · 2022Article
- Feedback-controlled photolytic gas phase nitric oxide delivery from S-nitrosothiol-doped silicone rubber films.Journal of controlled release : official journal of the Controlled Release Society · 2020Article
- Article
- MultifunctionalACS applied materials & interfaces · 2019Article
- Nitric Oxide Generation On Demand for Biomedical Applications via Electrocatalytic Nitrite Reduction by Copper BMPA- and BEPA-Carboxylate Complexes.ACS catalysis · 2019Article
- Crystal-facet-dependent denitrosylation: modulation of NO release fromChemical science · 2019Article
- Controlled light-induced gas phase nitric oxide release from S-nitrosothiol-doped silicone rubber films.Nitric oxide : biology and chemistry · 2019Article
- Liquid-Infused Nitric-Oxide-Releasing Silicone Foley Urinary Catheters for Prevention of Catheter-Associated Urinary Tract Infections.ACS biomaterials science & engineering · 2019Article
- Inhaled nitric oxide.British journal of pharmacology · 2019Review
- Comparison of Copper(II)-Ligand Complexes as Mediators for Preparing Electrochemically Modulated Nitric Oxide-Releasing Catheters.ACS applied materials & interfaces · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
A controllable and inexpensive electrochemical nitric oxide (NO) release system is demonstrated to improve hemocompatibility and reduce bacterial biofilm formation on biomedical devices. Nitric oxide is produced from the electrochemical reduction of nitrite using a copper(II)-tri(2-pyridylmethyl)amine (Cu(II)TPMA) complex as a mediator, and the temporal profile of NO release can be modulated readily by applying different cathodic potentials. Single lumen and dual lumen silicone rubber catheters are employed as initial model biomedical devices incorporating this novel NO release approach. The modified catheters can release a steady, physiologically-relevant flux of NO for more than 7 days. Both single and dual lumen catheters with continuous NO release exhibit greatly reduced thrombus formation on their surfaces after short-term 7-h intravascular placement in rabbit veins (p < 0.02, n = 6). Three day in vitro antimicrobial experiments, in which the catheters are "turned on" for only 3 h of NO release each day, exhibit more than a 100-fold decrease in the amount of surface attached live bacteria (n = 5). These results suggest that this electrochemical NO generation system could provide a robust and highly effective new approach to improving the thromboresistance and antimicrobial properties of intravascular catheters and potentially other biomedical devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.