ArticleFaraday discussions2013
The influence of the kinetics of self-assembly on the properties of dipeptide hydrogels.
Article in Faraday discussions, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Self-sorting and co-assembly control in multicomponent supramolecular hydrogels with dual monomer and polymer statistical distribution.Communications chemistry · 2025Article
- A Review on the Rheological Properties of Single Amino Acids and Short Dipeptide Gels.Gels (Basel, Switzerland) · 2024Review
- Enhancing the ROS Sensitivity of a Responsive Supramolecular Hydrogel Using Peroxizyme Catalysis.Biomacromolecules · 2023Article
- Using Solution History to Control Hydrogel Properties of a Perylene Bisimide.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Tuning Peptide-Based Hydrogels: Co-Assembly with Composites Driving the Highway to Technological Applications.International journal of molecular sciences · 2022Review
- One-Step Generation of Alginate-Based Hydrogel Foams Using COGels (Basel, Switzerland) · 2022Article
- Unravelling the Supramolecular Driving Forces in the Formation of COGels (Basel, Switzerland) · 2022Article
- Gelation Kinetics-Structure Analysis of pH-triggered Low Molecular Weight Hydrogelators.Chemphyschem : a European journal of chemical physics and physical chemistry · 2021Article
- Exploiting and controlling gel-to-crystal transitions in multicomponent supramolecular gels.Chemical science · 2021Article
- Impact of Citrate and Lipid-Functionalized Magnetic Nanoparticles in Dehydropeptide Supramolecular Magnetogels: Properties, Design and Drug Release.Nanomaterials (Basel, Switzerland) · 2020Article
- Isotopic Control over Self-Assembly in Supramolecular Gels.Langmuir : the ACS journal of surfaces and colloids · 2020Article
- Role of Sheet-Edge Interactions in β-sheet Self-Assembling Peptide Hydrogels.Biomacromolecules · 2020Article
- Chemical fuel-driven living and transient supramolecular polymerization.Nature communications · 2019Article
- Sub-zero temperature mechanically stable low molecular weight hydrogels.Journal of materials chemistry. B · 2018Article
- Magnetogels: Prospects and Main Challenges in Biomedical Applications.Pharmaceutics · 2018Review
- Controlling self-assembly of diphenylalanine peptides at high pH using heterocyclic capping groups.Scientific reports · 2017Article
- Peptide hydrogel in vitro non-inflammatory potential.Journal of peptide science : an official publication of the European Peptide Society · 2017Article
- Luminescent supramolecular hydrogels from a tripeptide and nitrogen-doped carbon nanodots.Beilstein journal of nanotechnology · 2017Article
- Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials.Chemical reviews · 2015Review
- Gelation Landscape Engineering Using a Multi-Reaction Supramolecular Hydrogelator System.Journal of the American Chemical Society · 2015Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We discuss the effect of the kinetics of pH change on the mechanical properties of dipeptide hydrogels. Data from other peptide-based low molecular weight gelator (LMWG) systems suggest that the rheological properties are often highly dependent on the assembly rate. To examine kinetics here, we have used the hydrolysis of glucono-8-lactone (GdL). The hydrolysis of GdL to gluconic acid results in a decrease in pH, the rate of which is temperature sensitive. Hence, we can adjust the rate of pH decrease, whilst achieving the same absolute final pH. Our data shows that at all temperatures the rheological profile is very similar, with an increase to a plateau, followed by a second increase in moduli, despite very different kinetics of assembly. Surprisingly, the final mechanical properties are very similar in all cases. We also show that the structures formed at the plateau can be accessed by adjusting the pH using CO2. By carefully balancing the pKa. of the gelator with the pH achievable using CO2, flexible hydrogel membranes can be formed as opposed to a bulk gel. The rheological characteristics of the membranes are typical of a highly entangled polymer network. These membranes can be rigidified by post-addition of GdL to further lower the pH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.