ArticleNutrition research and practice2014
Nephroprotective effect of astaxanthin against trivalent inorganic arsenic-induced renal injury in wistar rats.
Article in Nutrition research and practice, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- From nutrition to therapeutics: the diverse inflammopharmacological and biomedical roles of astaxanthin.Inflammopharmacology · 2026Review
- Article
- Changes in Oxidative Stress Parameters in Terms of Simultaneous Exposure to Physical and Chemical Factors: A Systematic Review.Iranian journal of public health · 2023Review
- Nephroprotective effect of magnesium isoglycyrrhizinate against arsenic trioxide-induced acute kidney damage in mice.Experimental and therapeutic medicine · 2022Article
- Astaxanthin Mitigates Thiacloprid-Induced Liver Injury and Immunotoxicity in Male Rats.Marine drugs · 2021Article
- Article
- Phytoremedial effect of Tinospora cordifolia against arsenic induced toxicity in Charles Foster rats.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2020Article
- Mechanisms underlying the protective effect of tannic acid against arsenic trioxide‑induced cardiotoxicity in rats: Potential involvement of mitochondrial apoptosis.Molecular medicine reports · 2020Article
- Renal accumulation of prooxidant mineral elements and CKD in domestic cats.Scientific reports · 2020Article
- Biochemical investigation of association of arsenic exposure with risk factors of diabetes mellitus in Pakistani population and its validation in animal model.Environmental monitoring and assessment · 2019Article
- Application of Herbal Traditional Chinese Medicine in the Treatment of Acute Kidney Injury.Frontiers in pharmacology · 2019Review
- Astaxanthin attenuates contrast agent-induced acute kidney injury in vitro and in vivo via the regulation of SIRT1/FOXO3a expression.International urology and nephrology · 2018Article
- Alteration in thiols homeostasis, protein and lipid peroxidation in renal tissue following subacute oral exposure of imidacloprid and arsenic in Wistar rats.Toxicology reports · 2018Article
- Effects of Olive Oil supplementation on Sodium Arsenate-induced Hepatotoxicity in Mice.International journal of preventive medicine · 2018Article
- Toxicodynamics of Lead, Cadmium, Mercury and Arsenic- induced kidney toxicity and treatment strategy: A mini review.Toxicology reports · 2018Review
- Differential toxicity of arsenic on renal oxidative damage and urinary metabolic profiles in normal and diabetic mice.Environmental science and pollution research international · 2017Article
- Dietary luteolin attenuates chronic liver injury induced by mercuric chloride via the Nrf2/NF-κB/P53 signaling pathway in rats.Oncotarget · 2017Article
- Influence of diet, vitamin, tea, trace elements and exogenous antioxidants on arsenic metabolism and toxicity.Environmental geochemistry and health · 2016Review
- Pathophysiological role of different tubular epithelial cell death modes in acute kidney injury.Clinical kidney journal · 2015Review
- The association of urine arsenic with prevalent and incident chronic kidney disease: evidence from the Strong Heart Study.Epidemiology (Cambridge, Mass.) · 2015Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inorganic arsenic (iAs) is a toxic metalloid found ubiquitously in the environment. In humans, exposure to iAs can result in toxicity and cause toxicological manifestations. Arsenic trioxide (As2O3) has been used in the treatment for acute promyelocytic leukemia. The kidney is the critical target organ of trivalent inorganic As (iAs(III)) toxicity. We examine if oral administration of astaxanthin (AST) has protective effects on nephrotoxicity and oxidative stress induced by As2O3 exposure (via intraperitoneal injection) in rats. Markers of renal function, histopathological changes, Na(+)-K(+) ATPase, sulfydryl, oxidative stress, and As accumulation in kidneys were evaluated as indicators of As2O3 exposure. AST showed a significant protective effect against As2O3-induced nephrotoxicity. These results suggest that the mechanisms of action, by which AST reduces nephrotoxicity, may include antioxidant protection against oxidative injury and reduction of As accumulation. These findings might be of therapeutic benefit in humans or animals suffering from exposure to iAs(III) from natural sources or cancer therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.