ArticleFrontiers in genetics2014
Delayed development induced by toxicity to the host can be inherited by a bacterial-dependent, transgenerational effect.
Article in Frontiers in genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 71 citations in OpenAlex.
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- Effects of in ovo stimulation with potential epigenetic modulators on immune system phenotype across three generations in a chicken model.Scientific reports · 2025Article
- A Model of Epigenetic Inheritance Accounts for Unexpected Adaptation to Unforeseen Challenges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
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- Sensing of the non-essential amino acid tyrosine governs the response to protein restriction in Drosophila.Nature metabolism · 2022Article
- Protocol for studying microbiome impact on host energy and reproduction inSTAR protocols · 2022Article
- Dynamic changes in species richness and community diversity of symbiotic bacteria in five reproductive morphs of cotton aphidFrontiers in microbiology · 2022Article
- Experimental inheritance of antibiotic acquired dysbiosis affects host phenotypes across generations.Frontiers in microbiology · 2022Article
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- Sodium Benzoate Delays the Development ofFrontiers in microbiology · 2022Article
- Activation of innate immunity during development induces unresolved dysbiotic inflammatory gut and shortens lifespan.Disease models & mechanisms · 2021Article
- Transgenerational non-genetic inheritance has fitness costs and benefits under recurring stress in the clonal duckweedProceedings. Biological sciences · 2021Article
- Chromosomal Sequence of Lactobacillus brevis Oregon-R-modENCODE Strain BDGP6, a Lactic Acid Bacterium Isolated from the Gut of Drosophila melanogaster.Microbiology resource announcements · 2020Article
- Influence of inoculated gut bacteria on the development of Bactrocera dorsalis and on its susceptibility to the entomopathogenic fungus, Metarhizium anisopliae.BMC microbiology · 2020Article
- Most dominant roles of insect gut bacteria: digestion, detoxification, or essential nutrient provision?Microbiome · 2020Article
- Trends in Symbiont-Induced Host Cellular Differentiation.Results and problems in cell differentiation · 2020Article
- Transgenerational epigenetic inheritance: from phenomena to molecular mechanisms.Current opinion in neurobiology · 2019Review
- Intergenerational and transgenerational epigenetic inheritance in animals.Nature cell biology · 2019Review
- The gut microbiome participates in transgenerational inheritance of low-temperature responses in Drosophila melanogaster.FEBS letters · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Commensal gut bacteria in many species including flies are integral part of their host, and are known to influence its development and homeostasis within generation. Here we report an unexpected impact of host-microbe interactions, which mediates multi-generational, non-Mendelian inheritance of a stress-induced phenotype. We have previously shown that exposure of fly larvae to G418 antibiotic induces transgenerationally heritable phenotypes, including a delay in larval development, gene induction in the gut and morphological changes. We now show that G418 selectively depletes commensal Acetobacter species and that this depletion explains the heritable delay, but not the inheritance of the other phenotypes. Notably, the inheritance of the delay was mediated by a surprising trans-generational effect. Specifically, bacterial removal from F1 embryos did not induce significant delay in F1 larvae, but nonetheless led to a considerable delay in F2. This effect maintains a delay induced by bacterial-independent G418 toxicity to the host. In line with these findings, reintroduction of isolated Acetobacter species prevented the inheritance of the delay. We further show that this prevention is partly mediated by vitamin B2 (Riboflavin) produced by these bacteria; exogenous Riboflavin led to partial prevention and inhibition of Riboflavin synthesis compromised the ability of the bacteria to prevent the inheritance. These results identify host-microbe interactions as a hitherto unrecognized factor capable of mediating non-Mendelian inheritance of a stress-induced phenotype.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.