ArticleThe Journal of infectious diseases2014
Association study of genes controlling IL-12-dependent IFN-γ immunity: STAT4 alleles increase risk of pulmonary tuberculosis in Morocco.
Article in The Journal of infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Polymorphic pseudogenes in the human genome - a comprehensive assessment.Human genetics · 2024Article
- Article
- STAT4 gene polymorphisms in human diseases.Frontiers in immunology · 2024Review
- Review
- Fulminant pulmonary tuberculosis in a previously healthy young woman from the Marshall Islands: Potential risk factors.Journal of clinical tuberculosis and other mycobacterial diseases · 2023Review
- Inborn errors of human transcription factors governing IFN-γ antimycobacterial immunity.Current opinion in immunology · 2023Review
- In vivo therapeutic success of MicroRNA-155 antagomir in a mouse model of pulmonary fibrosis induced by bleomycin.The Korean journal of internal medicine · 2021Article
- Tuberculosis susceptibility and protection in children.The Lancet. Infectious diseases · 2019Review
- 2'-5'-Oligoadenylate synthetase 1 polymorphisms are associated with tuberculosis: a case-control study.BMC pulmonary medicine · 2018Article
- Polymorphisms of theBioscience reports · 2018Article
- New variant identified in major susceptibility locus to tuberculosis on chromosomal region 8q12-q13 in Moroccan population: a case control study.BMC infectious diseases · 2017Article
- A Functional IL22 Polymorphism (rs2227473) Is Associated with Predisposition to Childhood Cerebral Malaria.Scientific reports · 2017Article
- Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype.mBio · 2016Article
- STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection.Scientific reports · 2016Article
- Pathway Analyses Identify Novel Variants in the WNT Signaling Pathway Associated with Tuberculosis in Chinese Population.Scientific reports · 2016Article
- No significant impact of IFN-γ pathway gene variants on tuberculosis susceptibility in a West African population.European journal of human genetics : EJHG · 2016Article
- A genome-wide association study of pulmonary tuberculosis in Morocco.Human genetics · 2016Article
- The variations of IL-23R are associated with susceptibility and severe clinical forms of pulmonary tuberculosis in Chinese Uygurs.BMC infectious diseases · 2015Article
- Pott's disease in Moroccan children: clinical features and investigation of the interleukin-12/interferon-γ pathway.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2015Article
- MicroRNA-155-IFN-γ Feedback Loop in CD4(+)T Cells of Erosive type Oral Lichen Planus.Scientific reports · 2015Article
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Authors and funding
21 authors at 10 institutions in 4 countries.
Funding
Abstract
backgroundOnly a minority of individuals infected with Mycobacterium tuberculosis develop clinical tuberculosis. Genetic epidemiological evidence suggests that pulmonary tuberculosis has a strong human genetic component. Previous genetic findings in Mendelian predisposition to more severe mycobacterial infections, including by M. tuberculosis, underlined the importance of the interleukin 12 (IL-12)/interferon γ (IFN-γ) circuit in antimycobacterial immunity.
methodsWe conducted an association study in Morocco between pulmonary tuberculosis and a panel of single-nucleotide polymorphisms (SNPs) covering 14 core IL-12/IFN-γ circuit genes. The analyses were performed in a discovery family-based sample followed by replication in a case-control population.
resultsOut of 228 SNPs tested in the family-based sample, 6 STAT4 SNPs were associated with pulmonary tuberculosis (P = .0013-.01). We replicated the same direction of association for 1 cluster of 3 SNPs encompassing the promoter region of STAT4. In the combined sample, the association was stronger among younger subjects (pulmonary tuberculosis onset <25 years) with an odds ratio of developing pulmonary tuberculosis at rs897200 for GG vs AG/AA subjects of 1.47 (1.06-2.04). Previous functional experiments showed that the G allele of rs897200 was associated with lower STAT4 expression.
conclusionsOur present findings in a Moroccan population support an association of pulmonary tuberculosis with STAT4 promoter-region polymorphisms that may impact STAT4 expression.
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