ArticleThe American journal of pathology1988
Evaluation of fibronectin gene expression by in situ hybridization. Differential expression of the fibronectin gene among populations of human alveolar macrophages.
Article in The American journal of pathology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Fibulin-1c regulates transforming growth factor-β activation in pulmonary tissue fibrosis.JCI insight · 2019Article
- Breast milk protects against the development of necrotizing enterocolitis through inhibition of Toll-like receptor 4 in the intestinal epithelium via activation of the epidermal growth factor receptor.Mucosal immunology · 2015Article
- Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice.The American journal of pathology · 2007Article
- Astrocyte-associated fibronectin is critical for axonal regeneration in adult white matter.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Article
- Light microscopical detection of inter-alpha-trypsin inhibitor and its different mRNAs in cultured hepatoma Hep G2 cells using immunocytochemical and in situ hybridization techniques.The Histochemical journal · 1994Article
- Article
- Neointimal macrophages colocalize with extracellular matrix gene expression in human atherosclerotic pulmonary arteries.The Journal of clinical investigation · 1993Article
- Fibronectin synthesis in subretinal membranes of proliferative vitreoretinopathy.The British journal of ophthalmology · 1992Article
- Secretory and accessory cell functions of the alveolar macrophage.Environmental health perspectives · 1992Article
- Localisation of fibronectin mRNA in the rheumatoid synovium by in situ hybridisation.Annals of the rheumatic diseases · 1992Article
- Local production of fibronectin by ectopic human retinal cells.Cell and tissue research · 1992Article
- Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Fibronectin in multiple sclerosis lesions.The American journal of pathology · 1989Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Populations of alveolar macrophages recovered from the lower respiratory tract secrete fibronectin, a multi-functional glycoprotein capable of influencing cell migration, attachment, differentiation, and proliferation. Using in situ hybridization of 35S-labeled antisense and sense RNA fibronectin probes, the present study demonstrates that most, but not all, normal alveolar macrophages contain fibronectin mRNA transcripts, and that among those macrophages expressing this gene, the relative amount of fibronectin mRNA transcripts varies from cell to cell. Interestingly, while 66 +/- 3% of normal alveolar macrophages contain fibronectin mRNA transcripts, this is increased to 82 +/- 2% (P less than 0.01) of alveolar macrophages recovered from the lungs of individuals with idiopathic pulmonary fibrosis (IPF), a chronic inflammatory disorder associated with exaggerated amounts of fibronectin in the lower respiratory tract. Furthermore, of the macrophages expressing the fibronectin gene, those from IPF patients contain more fibronectin mRNA transcripts than those from normals. Consistent with this observation, evaluation of tissue samples from IPF patients demonstrated that of all cells present, alveolar macrophages showed the greatest numbers of fibronectin mRNA transcripts per cell. These observations demonstrate that there can be marked cell-to-cell variation in the expression of the gene for a macrophage product such as fibronectin, suggesting that there are processes that modulate similar cells in the same anatomic compartment to vary their expression of the same gene.
Indexed as
Identifiers
2461087PMC1880771W1444867258What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.