Evidence map›Paper›PMID 24610821›Full record

ReviewJournal of immunology (Baltimore, Md. : 1950)2014

The immunology of food allergy.

Laura K Johnston, Karen B Chien, Paul J Bryce

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of immunology (Baltimore, Md. : 1950), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Diverging in Vivo Immune Response Patterns After Oral Food Challenge in Peanut Allergic Adults.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. IL-33 genetics and epigenetics in immune-related diseases.Clinical and molecular allergy : CMA · 2021
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Food Allergy: Searching for the Modern Environmental Culprit.The Yale journal of biology and medicine · 2020
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Laura K JohnstonDivision of Allergy-Immunology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago IL 60611.
Karen B Chien
Paul J Bryce
Northwestern University · US

Funding

TRAINING PROGRAM IN IMMUNOLOGY &MOLECULAR PATHOGENESIST32AI007476 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Edward Benjamin Thorp · 1996 to 2026
$6.6M
Regulation of T cell migration by histamineR01AI076456 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HULSE, KATHRYN ELIZABETH · 2008 to 2017
$3.9M
Regulation of food allergy and anaphylaxis by IL 33R01AI105839 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BOCHNER, BRUCE S · 2014 to 2018
$1.8M
NIAID NIH HHS R01 AI076456NIAID NIH HHS R01 AI105839NIAID NIH HHS T32 AI007476
6 · The paper itself

Abstract

Food allergies represent an increasingly prevalent human health problem, and therapeutic options remain limited, with avoidance being mainstay, despite its adverse effects on quality of life. A better understanding of the key immunological mechanisms involved in such responses likely will be vital for development of new therapies. This review outlines the current understanding of how the immune system is thought to contribute to prevention or development of food allergies. Drawing from animal studies, as well as clinical data when available, the importance of oral tolerance in sustaining immunological nonresponsiveness to food Ags, our current understanding of why oral tolerance may fail and sensitization may occur, and the knowledge of pathways that may lead to anaphylaxis and food allergy-associated responses are addressed.

Indexed as

AllergensAnaphylaxisAnimalsDesensitization, ImmunologicFood HypersensitivityHumansImmune SystemModels, ImmunologicalAllergens

Identifiers

PMID24610821
PMCPMC3988470
OpenAlexW2113635597

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.