ArticleAmerican journal of human genetics1988
Embryonic expression of the human 40-kD keratin: evidence from a processed pseudogene sequence.
Article in American journal of human genetics, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 75 citations in OpenAlex.
- Detection of circulating epithelial cells after surgery for benign breast disease.Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology · 2000Trial
- Cassia Angustifolia Primed ASCs Accelerate Burn Wound Healing by Modulation of Inflammatory Response.Tissue engineering and regenerative medicine · 2024Article
- The pseudogenes of eukaryotic translation elongation factors (EEFs): Role in cancer and other human diseases.Genes & diseases · 2022Review
- Expression analysis of human pterygium shows a predominance of conjunctival and limbal markers and genes associated with cell migration.Molecular vision · 2009Article
- The detection of circulating breast cancer cells in blood.Journal of clinical pathology · 2004Review
- Molecular detection of disseminated tumor cells in the peripheral blood in patients with gastrointestinal cancer.Journal of cancer research and clinical oncology · 2003Article
- Non-radioactive hybridization in microwells using enzyme linked immune sorbent assay for detection of RT-PCR-amplified CK19- and CEA-mRNA.Journal of Tongji Medical University = Tong ji yi ke da xue xue bao · 1999Article
- Reverse transcriptase/polymerase chain reaction detection of cytokeratin-19 mRNA in bone marrow and blood of breast cancer patients.Journal of cancer research and clinical oncology · 1996Article
- The molecular detection of circulating tumour cells.British journal of cancer · 1995Review
- Detection of epithelial cancer cells in peripheral blood by reverse transcriptase-polymerase chain reaction.British journal of cancer · 1995Article
- Epithelial-specific keratin gene expression: identification of a 300 base-pair controlling segment.Nucleic acids research · 1990Article
- Cloning and sequencing of a processed pseudogene derived from a human class III alcohol dehydrogenase gene.American journal of human genetics · 1990Article
- Re: Savtchenko et al. (1988): "Embryonic Expression of the Human 40-kD Keratin: Evidence from a Processed Pseudogene Sequence".American journal of human genetics · 1989Article
- Detection of circulating tumor cells in prostate cancer patients: methodological pitfalls and clinical relevance.Molecular medicine (Cambridge, Mass.)Review
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5 authors at 1 institution in 1 country.
Funding
Abstract
Analysis of the cytoskeletal components of early murine embryos has detected expression of two keratin proteins, K#8 and K#18, at the 4-8-cell stage. Comparable data for human embryos do not exist, although several processed pseudogenes corresponding to K#8 and K#18 have been discovered in the human genome. Because only genes that are expressed in pre-germ-line and germ-line cells can give rise to processed pseudogenes, the existence of human K#8 and K#18 processed pseudogenes is prima facie evidence for expression of keratins K#8 and K#18 in the early human embryo. We have cloned and determined the complete sequence of a processed pseudogene corresponding to another acidic human keratin. Comparison of its sequence with known sequences of other mammalian keratins indicates that the pseudogene arose from a reverse transcript of a correctly initiated and terminated functional human K#19 gene. This implies expression of K#19 keratin in addition to K#8 and K#18 in the early human embryo. We have proposed previously that K#19 evolved specifically to redress unbalanced production of various basic keratins, and our current evidence, that it is expressed at an early stage of development, implies that K#19 may fulfill this same role during human embryogenesis.
Indexed as
Identifiers
2461075PMC1715527W149066768What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.