ArticleHuman mutation2014
Gene conversion violates the stepwise mutation model for microsatellites in y-chromosomal palindromic repeats.
Article in Human mutation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- The Contribution of Massively Parallel Sequencing in Disclosing Unusual Tri- and Tetra-Allelic Type Patterns Detected at the Multicopy Loci DYS385a/b and DYF387S1.International journal of molecular sciences · 2026Article
- Case report on multilocus gene deletion and gene conversion at Y-STR loci.International journal of legal medicine · 2026Article
- CSYseq: The first Y-chromosome sequencing tool typing a large number of Y-SNPs and Y-STRs to unravel worldwide human population genetics.PLoS genetics · 2021Article
- Article
- Deletions and duplications of 42 Y chromosomal short tandem repeats in Chinese Han population.International journal of legal medicine · 2021Article
- Geographical structuring and low diversity of paternal lineages in Bahrain shown by analysis of 27 Y-STRs.Molecular genetics and genomics : MGG · 2020Article
- The Amazonian Red Side-Necked TurtleCells · 2020Article
- Comparative genome analysis of 52 fish species suggests differential associations of repetitive elements with their living aquatic environments.BMC genomics · 2018Article
- The annotation of repetitive elements in the genome of channel catfish (Ictalurus punctatus).PloS one · 2018Article
- Human Y-chromosome variation in the genome-sequencing era.Nature reviews. Genetics · 2017Review
- Y chromosome palindromes and gene conversion.Human genetics · 2017Review
- The Y chromosomes of the great apes.Human genetics · 2017Review
- Article
- Y chromosome haplotype diversity in Mongolic-speaking populations and gene conversion at the duplicated STR DYS385a,b in haplogroup C3-M407.Journal of human genetics · 2016Article
- When homoplasy mimics hybridization: a case study of Cape hakes (Merluccius capensis and M. paradoxus).PeerJ · 2016Article
- Y chromosome of Aisin Gioro, the imperial house of the Qing dynasty.Journal of human genetics · 2015Article
- The Y-chromosome tree bursts into leaf: 13,000 high-confidence SNPs covering the majority of known clades.Molecular biology and evolution · 2015Article
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
The male-specific region of the human Y chromosome (MSY) contains eight large inverted repeats (palindromes), in which high-sequence similarity between repeat arms is maintained by gene conversion. These palindromes also harbor microsatellites, considered to evolve via a stepwise mutation model (SMM). Here, we ask whether gene conversion between palindrome microsatellites contributes to their mutational dynamics. First, we study the duplicated tetranucleotide microsatellite DYS385a,b lying in palindrome P4. We show, by comparing observed data with simulated data under a SMM within haplogroups, that observed heteroallelic combinations in which the modal repeat number difference between copies was large, can give rise to homoallelic combinations with zero-repeats difference, equivalent to many single-step mutations. These are unlikely to be generated under a strict SMM, suggesting the action of gene conversion. Second, we show that the intercopy repeat number difference for a large set of duplicated microsatellites in all palindromes in the MSY reference sequence is significantly reduced compared with that for nonpalindrome-duplicated microsatellites, suggesting that the former are characterized by unusual evolutionary dynamics. These observations indicate that gene conversion violates the SMM for microsatellites in palindromes, homogenizing copies within individual Y chromosomes, but increasing overall haplotype diversity among chromosomes within related groups.
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