ArticleJournal of applied physiology (Bethesda, Md. : 1985)2014
Effect of acute hypoxia on regional cerebral blood flow: effect of sympathetic nerve activity.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 62 citations in OpenAlex.
- Unexpected reductions in regional cerebral perfusion during prolonged hypoxia.The Journal of physiology · 2017Trial
- Cerebrovascular reactivity is increased with acclimatization to 3,454 m altitude.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Trial
- Cerebrovascular reactivity differences in healthy cerebral gray and white matter.Magnetic resonance in medicine · 2025Article
- Free-moving-state microscopic imaging of cerebral oxygenation and hemodynamics with a photoacoustic fiberscope.Light, science & applications · 2024Article
- The Role of PRRC2B in Cerebral Vascular Remodeling Under Acute Hypoxia in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Real-time whole-brain imaging of hemodynamics and oxygenation at micro-vessel resolution with ultrafast wide-field photoacoustic microscopy.Light, science & applications · 2022Article
- Effect of a day-trip to altitude (2500 m) on exercise performance in pulmonary hypertension: randomised crossover trial.ERJ open research · 2021Article
- Revisiting the neurovascular unit.Nature neuroscience · 2021Review
- Impact of acute changes in blood pressure and arterial stiffness on cerebral pulsatile haemodynamics in young and middle-aged adults.Experimental physiology · 2021Article
- Assessment of cerebrovascular responses to physiological stimuli in identical twins using multimodal imaging and computational fluid dynamics.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Impact of stroke co-morbidities on cortical collateral flow following ischaemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Altered Cerebral Blood Flow and Potential Neuroprotective Effect of Human Relaxin-2 (Serelaxin) During Hypoxia or Severe Hypovolemia in a Sheep Model.International journal of molecular sciences · 2020Article
- Specific effect of hypobaria on cerebrovascular hypercapnic responses in hypoxia.Physiological reports · 2020Article
- Differential contribution of cyclooxygenase to basal cerebral blood flow and hypoxic cerebral vasodilation.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Steady-state cerebral blood flow regulation at altitude: interaction between oxygen and carbon dioxide.European journal of applied physiology · 2019Article
- Cerebral Blood Flow, Oxygen Delivery, and Pulsatility Responses to Oxygen Inhalation at High Altitude: Highlanders vs. Lowlanders.Frontiers in physiology · 2019Article
- Regulation of regional cerebral blood flow during graded reflex-mediated sympathetic activation via lower body negative pressure.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Ventilatory and cerebrovascular regulation and integration at high-altitude.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2018Review
- Reduced arterial vasodilatation in response to hypoxia impairs cerebral and peripheral oxygen delivery in hypertensive men.The Journal of physiology · 2018Article
- Cerebrovascular and ventilatory responses to acute normobaric hypoxia in girls and women.Physiological reports · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined 1) whether global cerebral blood flow (CBF) would increase across a 6-h bout of normobaric poikilocapnic hypoxia and be mediated by a larger increase in blood flow in the vertebral artery (VA) than in the internal carotid artery (ICA); and 2) whether additional increases in global CBF would be evident following an α1-adrenergic blockade via further dilation of the ICA and VA. In 11 young normotensive individuals, ultrasound measures of ICA and VA flow were obtained in normoxia (baseline) and following 60, 210, and 330 min of hypoxia (FiO2 = 0.11). Ninety minutes prior to final assessment, participants received an α1-adrenoreceptor blocker (prazosin, 1 mg/20 kg body mass) or placebo. Compared with baseline, following 60, 220, and 330 min of hypoxia, global CBF [(ICAFlow + VAFlow) ∗ 2] increased by 160 ± 52 ml/min (+28%; P = 0.05), 134 ± 23 ml/min (+23%; P = 0.02), and 113 ± 51 (+19%; P = 0.27), respectively. Compared with baseline, ICAFlow increased by 23% following 60 min of hypoxia (P = 0.06), after which it progressively declined. The percentage increase in VA flow was consistently larger than ICA flow during hypoxia by ∼20% (P = 0.002). Compared with baseline, ICA and VA diameters increased during hypoxia by ∼9% and ∼12%, respectively (P ≤ 0.05), and were correlated with reductions in SaO2. Flow and diameters were unaltered following α1 blockade (P ≥ 0.10). In conclusion, elevations in global CBF during acute hypoxia are partly mediated via greater increases in VA flow compared with ICA flow; this regional difference was unaltered following α1 blockade, indicating that a heightened sympathetic nerve activity with hypoxia does not constrain further dilation of larger extracranial blood vessels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.