ArticleCerebral cortex (New York, N.Y. : 1991)2015
Experience-Dependent, Layer-Specific Development of Divergent Thalamocortical Connectivity.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Time-dependent phenotypical changes of microglia drive alterations in hippocampal synaptic transmission in acute slices.Frontiers in cellular neuroscience · 2024Article
- Evaluation of advances in cortical development using model systems.Developmental neurobiology · 2022Review
- Review
- The extracellular matrix regulates cortical layer dynamics and cross-columnar frequency integration in the auditory cortex.Communications biology · 2021Article
- Aberrant development of excitatory circuits to inhibitory neurons in the primary visual cortex after neonatal binocular enucleation.Scientific reports · 2021Article
- Active Sleep Promotes Coherent Oscillatory Activity in the Cortico-Hippocampal System of Infant Rats.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Transient Subgranular Hyperconnectivity to L2/3 and Enhanced Pairwise Correlations During the Critical Period in the Mouse Auditory Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Altered dendritic spine function and integration in a mouse model of fragile X syndrome.Nature communications · 2019Article
- Precision in the development of neocortical architecture: From progenitors to cortical networks.Progress in neurobiology · 2019Review
- Developmental trajectory of movement-related cortical oscillations during active sleep in a cross-sectional cohort of pre-term and full-term human infants.Scientific reports · 2018Article
- Active Sleep Promotes Functional Connectivity in Developing Sensorimotor Networks.BioEssays : news and reviews in molecular, cellular and developmental biology · 2018Article
- Pharmacodynamics of the Glutamate Receptor Antagonists in the Rat Barrel Cortex.Frontiers in pharmacology · 2018Article
- Reduced local input to fast-spiking interneurons in the somatosensory cortex in the GABAEpilepsia · 2017Article
- Alterations in the properties of neonatal thalamocortical synapses with time in in vitro slices.PloS one · 2017Article
- The Nature of the Sensory Input to the Neonatal Rat Barrel Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Altered thalamocortical development in the SAP102 knockout model of intellectual disability.Human molecular genetics · 2016Article
- Article
- Developmental Changes in Electrophysiological Properties and a Transition from Electrical to Chemical Coupling between Excitatory Layer 4 Neurons in the Rat Barrel Cortex.Frontiers in neural circuits · 2016Article
- Unbiased, High-Throughput Electron Microscopy Analysis of Experience-Dependent Synaptic Changes in the Neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
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Authors and funding
5 authors.
Funding
Abstract
The main input to primary sensory cortex is via thalamocortical (TC) axons that form the greatest number of synapses in layer 4, but also synapse onto neurons in layer 6. The development of the TC input to layer 4 has been widely studied, but less is known about the development of the layer 6 input. Here, we show that, in neonates, the input to layer 6 is as strong as that to layer 4. Throughout the first postnatal week, there is an experience-dependent strengthening specific to layer 4, which correlates with the ability of synapses in layer 4, but not in layer 6, to undergo long-term potentiation (LTP). This strengthening consists of an increase in axon branching and the divergence of connectivity in layer 4 without a change in the strength of individual connections. We propose that experience-driven LTP stabilizes transient TC synapses in layer 4 to increase strength and divergence specifically in layer 4 over layer 6.
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