ArticleCerebral cortex (New York, N.Y. : 1991)2015
Developmental Expression Patterns of GABAA Receptor Subunits in Layer 3 and 5 Pyramidal Cells of Monkey Prefrontal Cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 61 citations in OpenAlex.
- Variability vs. phenotype: Multimodal analysis of Dravet syndrome brain organoids powered by deep learning.iScience · 2025Article
- Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling.Science advances · 2025Article
- Cell Type-Specific Profiles and Developmental Trajectories of Transcriptomes in Primate Prefrontal Layer 3 Pyramidal Neurons: Implications for Schizophrenia.The American journal of psychiatry · 2024Article
- GABA system as the cause and effect in early development.Neuroscience and biobehavioral reviews · 2024Review
- Extrasynaptic δGABAA receptors mediate resistance to migraine-like phenotype in rats.The journal of headache and pain · 2024Article
- Maturation of glutamatergic transmission onto dorsal raphe serotonergic neurons.Journal of neurophysiology · 2024Article
- Cortical origin of theta error signals.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- CGP7930 - An allosteric modulator of GABANeuropharmacology · 2023Article
- Strength of Excitatory Inputs to Layer 3 Pyramidal Neurons During Synaptic Pruning in the Monkey Prefrontal Cortex: Relevance for the Pathogenesis of Schizophrenia.Biological psychiatry · 2023Article
- Mechanisms regulating the properties of inhibition-based gamma oscillations in primate prefrontal and parietal cortices.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Development of frontal GABA and glutamate supports excitation/inhibition balance from adolescence into adulthood.Progress in neurobiology · 2022Article
- Cognitive Dysfunction and Prefrontal Cortical Circuit Alterations in Schizophrenia: Developmental Trajectories.Biological psychiatry · 2022Review
- Altered Development of Prefrontal GABAergic Functions and Anxiety-like Behavior in Adolescent Offspring Induced by Prenatal Stress.Brain sciences · 2022Article
- Differential assembly diversifies GABANature · 2022Article
- Human ARHGEF9 intellectual disability syndrome is phenocopied by a mutation that disrupts collybistin binding to the GABAMolecular psychiatry · 2022Article
- A developmental reduction of the excitation:inhibition ratio in association cortex during adolescence.Science advances · 2022Article
- MicroRNAs in the Onset of Schizophrenia.Cells · 2021Review
- The role of GABAergic signalling in neurodevelopmental disorders.Nature reviews. Neuroscience · 2021Review
- Postnatal Development of Glutamate and GABA Transcript Expression in Monkey Visual, Parietal, and Prefrontal Cortices.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Laminar Differences in the Targeting of Dendritic Spines by Cortical Pyramidal Neurons and Interneurons in Human Dorsolateral Prefrontal Cortex.Neuroscience · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cortical pyramidal neuron activity is regulated in part through inhibitory inputs mediated by GABAA receptors. The subunit composition of these receptors confers distinct functional properties. Thus, developmental shifts in subunit expression will likely influence the characteristics of pyramidal cell firing and the functional maturation of processes that depend on these neurons. We used laser microdissection and PCR to quantify postnatal developmental changes in the expression of GABAA receptor subunits (α1, α2, α5, β2, γ2, and δ) in layer 3 pyramidal cells of monkey prefrontal cortex, which are critical for working memory. To determine the specificity of these changes, we examined glutamate receptor subunits (AMPA Glur1 and NMDA Grin1) and conducted the same analyses in layer 5 pyramidal cells. Expression of GABAA receptor subunit mRNAs changed substantially, whereas glutamate receptor subunit changes were modest over postnatal development. Some transcripts (e.g., GABAA α1) progressively increased from birth until adulthood, whereas others (e.g., GABAA α2) declined with age. Changes in some transcripts were present in only one layer (e.g., GABAA δ). The development of GABAA receptor subunit expression in primate prefrontal pyramidal neurons is protracted and subunit- and layer-specific. These trajectories might contribute to the molecular basis for the maturation of working memory.
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