Evidence map›Paper›PMID 24610035›Full record

ReviewJournal of anesthesia2014

Cellular signaling pathways and molecular mechanisms involving inhalational anesthetics-induced organoprotection.

Lingzhi Wu, Hailin Zhao, Tianlong Wang, Chen Pac-Soo, Daqing Ma

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Journal of anesthesia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05315648 (The Associations Between Perioperative Depression or Anxiety, Salivary Cortisol and α-amylase, and Administered Anesthesia Type in Knee Arthroscopy With Anterior Cruciate Ligament Reconstruction), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05315648 nacompletednot on this mapstarted 2021, after this paper: background citation

The Associations Between Perioperative Depression or Anxiety, Salivary Cortisol and α-amylase, and Administered Anesthesia Type in Knee Arthroscopy With Anterior Cruciate Ligament Reconstruction (ACLR): Prospective, Randomized Trial

TypeinterventionalSponsorSecond Affiliated Hospital of Wenzhou Medical UniversityRan2021 to 2024Enrolled162ConditionsDepression, AnxietyArmsanesthesia approach (general anesthesia or non-general anesthesia)
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 35 citations in OpenAlex.

  1. Trial
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  5. Article
  6. Inhaled Anesthetics: Beyond the Operating Room.Journal of clinical medicine · 2024
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
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  16. Review
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  18. Article
  19. Review
  20. Effect of Inhalation Anesthetics on Tumor Metastasis.Technology in cancer research & treatment
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Lingzhi WuSection of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK.
Hailin Zhao
Tianlong Wang
Chen Pac-Soo
Daqing Ma
Imperial College London · GBCapital Medical University · CNChelsea and Westminster Hospital · GB

Funding

Medical Research Council G0802392
6 · The paper itself

Abstract

Inhalational anesthetics-induced organoprotection has received much research interest and has been consistently demonstrated in different models of organ damage, in particular, ischemia-reperfusion injury, which features prominently in the perioperative period and in cardiovascular events. The cellular mechanisms accountable for effective organoprotection over heart, brain, kidneys, and other vital organs have been elucidated in turn in the past two decades, including receptor stimulations, second-messenger signal relay and amplification, end-effector activation, and transcriptional modification. This review summarizes the signaling pathways and the molecular participants in inhalational anesthetics-mediated organ protection published in the current literature, comparing and contrasting the 'preconditioning' and 'postconditioning' phenomena, and the similarities and differences in mechanisms between organs. The salubrious effects of inhalational anesthetics on vital organs, if reproducible in human subjects in clinical settings, would be of exceptional clinical importance, but clinical studies with better design and execution are prerequisites for valid conclusions to be made. Xenon as the emerging inhalational anesthetic, and its organoprotective efficacy, mechanism, and relative advantages over other anesthetics, are also discussed.

Indexed as

Anesthetics, InhalationAnimalsBrainHeartHumansPerioperative PeriodReperfusion InjurySignal TransductionAnesthetics, Inhalation

Identifiers

PMID24610035
OpenAlexW1982380684

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.