ArticleJournal of neurology2014
Comparative clinical characteristics of neuromyelitis optica spectrum disorders with and without medulla oblongata lesions.
Article in Journal of neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Worldwide prevalence of neuromyelitis optica spectrum disorder (NMOSD) and neuromyelitis optica (NMO): a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Pooled it
- Long-term disability in neuromyelitis optica spectrum disorder with a history of myelitis is associated with age at onset, delay in diagnosis/preventive treatment, MRI lesion length and presence of symptomatic brain lesions.Multiple sclerosis and related disorders · 2019Pooled it
- Relapse-related outcomes in the Danish population-based AQP4- antibody seropositive neuromyelitis optica spectrum disorder cohort.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Multimodal MRI biomarkers and machine learning in neuromyelitis optica spectrum disorder: a review.Frontiers in neurology · 2026Review
- Relative frequency of primary headaches in patients with neuromyelitis optica spectrum disorder: A cross-sectional study.Current journal of neurology · 2024Article
- Neuromyelitis optica spectrum disorder with acute brainstem manifestations as initial symptoms.Heliyon · 2024Article
- Characteristics of recurrence in area postrema-onset NMO spectrum disorder - a retrospective cohort study.BMC neurology · 2024Article
- Autoimmune Neurogenic Dysphagia.Dysphagia · 2022Review
- Clinical and prognostic aspects of patients with the Neuromyelitis Optica Spectrum Disorder (NMOSD) from a cohort in Northeast Brazil.BMC neurology · 2022Article
- Botulinum toxin injection combined with traditional swallowing rehabilitation improved cricopharyngeal dysfunction in neuromyelitis optica spectrum disorder: A case report.Frontiers in neurology · 2022Article
- Pain in NMOSD and MOGAD: A Systematic Literature Review of Pathophysiology, Symptoms, and Current Treatment Strategies.Frontiers in neurology · 2020Review
- Autoimmune glial fibrillary acidic protein astrocytopathy with lesions distributed predominantly in the entire spinal cord.Therapeutic advances in neurological disorders · 2020Article
- Pattern Recognition of the Multiple Sclerosis Syndrome.Brain sciences · 2017Review
- Headache in Neuromyelitis Optica.Current pain and headache reports · 2017Review
- Paroxysmal sneezing in NMOSD: Further evidence of the localization of the human sneeze center.Neurology(R) neuroimmunology & neuroinflammation · 2017Article
- The role of anti-aquaporin 4 antibody in the conversion of acute brainstem syndrome to neuromyelitis optica.BMC neurology · 2016Article
- Neuromyelitis optica spectrum disorders with multiple brainstem manifestations: a case report.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2016Article
- Comparison of clinical characteristics between neuromyelitis optica spectrum disorders with and without spinal cord atrophy.BMC neurology · 2014Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brainstem involvement, especially the medulla oblongata (MO), has been reported in neuromyelitis optica spectrum disorders (NMOSDs). The purpose of this study was to investigate retrospectively and compare clinical, laboratory, and imaging features of NMOSDs with and without MO lesions. A total of 170 patients with NMOSDs were enrolled, including 44 patients with MO lesions and 126 patients without MO lesions. Clinical features, laboratory tests, and magnetic resonance imaging findings among these patients were assessed. MO lesions were found in 25.9 % of the NMOSDs patients. The mean duration was 13 months. Patients with MO lesions had a higher Annualized relapse rate and Expanded Disability Status Score Scale. Headache, dizziness, nystagmus, dysarthria, intractable hiccup and nausea, choking cough or dysphagia, movement disorders, and neuropathic pain were more common in MO lesion patients. Patients with MO lesions were more frequently complicated with thyroid diseases. Multiple brain involvement, More importantly, Longitudinally extensive transverse myelitis were more frequently found in patients with MO lesions. MO lesions might be a symbol of more severe neurologic deficits and worse prognosis of NMOSDs.
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