Evidence map›Paper›PMID 24609842›Full record

ArticleJournal of youth and adolescence2014

Are stressful developmental processes of youths leading to health problems amplified by genetic polymorphisms? The case of body mass index.

Kandauda K A S Wickrama, Catherine Walker O'Neal, Assaf Oshri

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Article in Journal of youth and adolescence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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  5. Article
  6. Article
  7. Review
  8. Article
  9. The 2013 Elliott Youth Development Lecture.Journal of youth and adolescence · 2015
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

3 authors.

Kandauda K A S WickramaDepartment of Human Development and Family Science, 103 Family Science Center I, University of Georgia, Athens, GA, USA, wickrama@uga.edu.
Catherine Walker O'Neal
Assaf Oshri

Funding

Wave IV Data CollectionP01HD031921 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HARRIS, KATHLEEN MULLAN · 1994 to 2020
$86.1M
NICHD NIH HHS P01 HD31921
6 · The paper itself

Abstract

Although previous research has documented the adverse influence of early socioeconomic disadvantage on youths' physical health outcomes and the increase in health inequalities over the early life course, little is known about genetically informed sequential life course developmental processes leading to health outcomes. Consistent with the life course-stress process perspective, we hypothesized that early socioeconomic adversity initiates a stress process over the early life course. This process involves the disrupted transition from adolescence to young adulthood, which increases the risk of health problems during young adulthood. Behavioral, psychosocial, and genetic data were collected from 12,424 adolescents (53 % female) over a period of 13 years participating in the nationally representative National Longitudinal Study of Adolescent Health (Add Health). Early cumulative socioeconomic adversity and the polygenic influence were measured using composite indices. The study provided evidence for stressful developmental processes of adolescents, involving parental rejection, depressive symptoms, and adolescents' precocious transition. This longitudinal process was initiated by early cumulative socioeconomic adversity and eventuated with young adults' increased body mass index (BMI). Furthermore, the study provided evidence for the influence of life context-gene interactions (G × E) on adolescents' precocious development and young adult BMI (after controlling for the lagged measure) amplifying the stress process over the early life course. These findings emphasize the need for incorporating individual genetic characteristics in a longitudinal context into life course stress research. Furthermore, policies focused on eradicating childhood/adolescent adversities are necessary as well as youth programs and policies that promote youth competencies that aid in their successful transition to young adulthood.

Indexed as

Body Mass IndexEpistasis, GeneticPolymorphism, GeneticAdolescentAdolescent DevelopmentChildFemaleHumansLongitudinal StudiesMaleModels, BiologicalModels, StatisticalNational Longitudinal Study of Adolescent HealthObesityParent-Child RelationsRisk Factors

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.