ArticlePloS one2014
Abnormal default-mode network homogeneity in first-episode, drug-naive major depressive disorder.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Reduced functional connectivity of default mode network subsystems in depression: Meta-analytic evidence and relationship with trait rumination.NeuroImage. Clinical · 2021Pooled it
- Pooled it
- Shared and distinct alterations in brain connectivity and cognitive function in subthreshold and major depression.Psychological medicine · 2026Article
- Association of sleep symptom burden with default mode network homogeneity in first-episode drug-naïve adolescents with major depressive disorder.Frontiers in psychiatry · 2026Article
- Multivariate Neural Markers of Individual Differences in Thought Control Difficulties.bioRxiv : the preprint server for biology · 2025Article
- Cerebellar contribution to emotion regulation and its association with medial frontal GABA level.Social cognitive and affective neuroscience · 2025Article
- Multivariate neural markers of individual differences in thought control difficulties.NeuroImage. Clinical · 2025Article
- Article
- Potential correlations between abnormal homogeneity of default mode network and personality or lipid level in major depressive disorder.Brain and behavior · 2024Article
- Aberrant resting-state co-activation network dynamics in major depressive disorder.Translational psychiatry · 2024Article
- Findings of PTSD-specific deficits in default mode network strength following a mild experimental stressor.NPP - digital psychiatry and neuroscience · 2024Article
- Differential effects of hypnotherapy and cognitive behavioral therapy on the default mode network of depressed patients.Frontiers in psychology · 2024Article
- Association between abnormal default mode network homogeneity and sleep disturbances in major depressive disorder.General psychiatry · 2024Article
- Psychological resilience mediates the protective role of default-mode network functional connectivity against COVID-19 vicarious traumatization.Translational psychiatry · 2023Article
- Heterogeneous brain dynamic functional connectivity patterns in first-episode drug-naive patients with major depressive disorder.Human brain mapping · 2023Article
- The Bilateral Precuneus as a Potential Neuroimaging Biomarker for Right Temporal Lobe Epilepsy: A Support Vector Machine Analysis.Frontiers in psychiatry · 2022Article
- Abnormal network homogeneity of default-mode network and its relationships with clinical symptoms in antipsychotic-naïve first-diagnosis schizophrenia.Frontiers in neuroscience · 2022Article
- Comparative analysis of default mode networks in major psychiatric disorders using resting-state EEG.Scientific reports · 2021Article
- Altered interhemispheric functional homotopy and connectivity in temporal lobe epilepsy based on fMRI and multivariate pattern analysis.Neuroradiology · 2021Article
- Crosstalk between Existential Phenomenological Psychotherapy and Neurological Sciences in Mood and Anxiety Disorders.Biomedicines · 2021Review
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Authors and funding
8 authors.
Funding
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Abstract
backgroundDefault mode network (DMN) is one of the most commonly recognized resting-state networks in major depressive disorder (MDD). However, the homogeneity of this network in MDD is poorly understood. As such, this study was conducted to determine whether or not an abnormal network homogeneity (NH) of DMN is observed in patients with first-episode and drug-naive MDD.
methodsTwenty-four first-episode drug-naive patients with MDD and twenty-four healthy control subjects participated in the study. NH and independent component analysis (ICA) methods were used to analyze data.
resultsDepressed patients exhibited a significantly increased NH in the left dorsal medial prefrontal cortex (MPFC) and decreased NH in the right inferior temporal gyrus (ITG) compared with the healthy control subjects. Receiver operating characteristic curves (ROC) were analyzed and results revealed that the NH values of MPFC and ITG could be applied as candidate markers with relatively high sensitivity and specificity to distinguish patients from healthy control subjects. No correlation was observed between the NH values of the two regions and clinical variables.
conclusionsOur findings suggested that an abnormal DMN homogeneity could be observed in MDD, which highlight the importance of the DMN in the pathophysiology of MDD.
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