ArticleProceedings of the National Academy of Sciences of the United States of America1988
Interleukin 3 binds to a 140-kDa phosphotyrosine-containing cell surface protein.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 103 citations in OpenAlex.
- Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.The EMBO journal · 1995Article
- Differential regulation of early response genes and cell proliferation through the human granulocyte macrophage colony-stimulating factor receptor: selective activation of the c-fos promoter by genistein.Molecular biology of the cell · 1993Article
- Ligand-dependent transformation by the receptor for human granulocyte/macrophage colony-stimulating factor and tyrosine phosphorylation of the receptor beta subunit.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Association of p56lck with IL-2 receptor beta chain is critical for the IL-2-induced activation of p56lck.The EMBO journal · 1993Article
- Ligand-induced phosphorylation of the murine interleukin 3 receptor signals its cleavage.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Cytokine receptors: structure and signal transduction.Clinical and experimental immunology · 1992Review
- In vitro phosphorylation of the erythropoietin receptor and an associated protein, pp130.Molecular and cellular biology · 1992Article
- Induction of tyrosine phosphorylation by the erythropoietin receptor correlates with mitogenesis.Molecular and cellular biology · 1991Article
- Molecular basis of a high affinity murine interleukin-5 receptor.The EMBO journal · 1991Article
- Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Signal transduction of human interleukin 3 and granulocyte-macrophage colony-stimulating factor through serine and tyrosine phosphorylation.The Biochemical journal · 1990Article
- Growth factor-dependent initiation of DNA replication in nuclei isolated from an interleukin 3-dependent murine myeloid cell line.The Journal of clinical investigation · 1990Article
- Hematopoietic growth factor receptors.Cytotechnology · 1989Article
- EGF induces differentiation of an IL-3-dependent cell line expressing the EGF receptor.The EMBO journal · 1989Article
- Tyrosine kinase oncogenes abrogate interleukin-3 dependence of murine myeloid cells through signaling pathways involving c-myc: conditional regulation of c-myc transcription by temperature-sensitive v-abl.Molecular and cellular biology · 1989Article
- Reversible abrogation of IL-3 dependence by an inducible H-ras oncogene.The EMBO journal · 1989Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Interleukin 3 (IL-3) is a hematopoietic growth factor that supports the proliferation and differentiation of early hematopoietic-lineage progenitors. By using growth factor-dependent cell lines, IL-3 has been shown to induce the appearance of several phosphotyrosine-containing proteins, including a 140-kDa cell surface phosphoprotein. Here we demonstrate that the 140-kDa phosphoprotein binds IL-3 and forms a stable complex with an apparent molecular mass of 170 kDa. The possible relationship of the 140-kDa phosphoprotein to the previously described 65-kDa IL-3-binding protein is discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.