ArticleJournal of neural engineering2014
Methods for implantation of micro-wire bundles and optimization of single/multi-unit recordings from human mesial temporal lobe.
Article in Journal of neural engineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 72 citations in OpenAlex.
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- Brain-wide single-neuron bases of working memory for sounds in humans.bioRxiv : the preprint server for biology · 2025Article
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- Microelectrode Implantation in Human Insula: Technical Challenges and Recording Insights.Brain sciences · 2025Article
- Electrode Arrays for Detecting and Modulating Deep Brain Neural Information in Primates: A Review.Cyborg and bionic systems (Washington, D.C.) · 2025Review
- Single unit-derived connectivity networks in tuberous sclerosis complex reveal propensity for network hypersynchrony driven by tuber-tuber interactions.Scientific reports · 2024Article
- Direct visualization of microwires in hybrid depth electrodes using high-resolution photon-counting CT.Epilepsia open · 2024Article
- Interictal epileptiform discharges affect memory in an Alzheimer's disease mouse model.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Spatiotemporal spike-centered averaging reveals symmetry of temporal and spatial components of the spike-LFP relationship during human focal seizures.Communications biology · 2023Article
- Making a case for endovascular approaches for neural recording and stimulation.Journal of neural engineering · 2023Review
- Local networks from different parts of the human cerebral cortex generate and share the same population dynamic.Cerebral cortex communications · 2022Article
- Duplicate Detection of Spike Events: A Relevant Problem in Human Single-Unit Recordings.Brain sciences · 2021Article
- Face-Selective Units in Human Ventral Temporal Cortex Reactivate during Free Recall.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The Argo: a high channel count recording system for neural recording in vivo.Journal of neural engineering · 2021Article
- Neuronal Firing and Waveform Alterations through Ictal Recruitment in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Dual mechanisms of ictal high frequency oscillations in human rhythmic onset seizures.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe authors report methods developed for the implantation of micro-wire bundles into mesial temporal lobe structures and subsequent single neuron recording in epileptic patients undergoing in-patient diagnostic monitoring. This is done with the intention of lowering the perceived barriers to routine single neuron recording from deep brain structures in the clinical setting. APPROACH: Over a 15 month period, 11 patients were implanted with platinum micro-wire bundles into mesial temporal structures. Protocols were developed for (A) monitoring electrode integrity through impedance testing, (B) ensuring continuous 24-7 recording, (C) localizing micro-wire position and 'splay' pattern and (D) monitoring grounding and referencing to maintain the quality of recordings. MAIN
resultsFive common modes of failure were identified: (1) broken micro-wires from acute tensile force, (2) broken micro-wires from cyclic fatigue at stress points, (3) poor in vivo micro-electrode separation, (4) motion artifact and (5) deteriorating ground connection and subsequent drop in common mode noise rejection. Single neurons have been observed up to 14 days post-implantation and on 40% of micro-wires. SIGNIFICANCE: Long-term success requires detailed review of each implant by both the clinical and research teams to identify failure modes, and appropriate refinement of techniques while moving forward. This approach leads to reliable unit recordings without prolonging operative times, which will help increase the availability and clinical viability of human single neuron data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.