ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014
Regulation of the mouse medial prefrontal cortical synapses by endogenous estradiol.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 63 citations in OpenAlex.
- Age-Related Changes in Density, Arborization, and NMDA Receptor Expression in Somatostatin Interneurons of the Mouse mPFC.The Journal of comparative neurology · 2026Article
- Acute Stress Drives Adaptive Anxiety via Excitatory-Inhibitory Imbalance in the Prefrontal-Amygdala Circuit in Male Mice.Neuroscience bulletin · 2026Article
- Synaptic Actions of Estradiol in the Brain's Reward System: Linking Mechanisms to Behavior and Disease.Biological psychiatry global open science · 2026Review
- Synaptic, cellular, and circuit mechanisms underlying sex differences in behaviors.Biology of sex differences · 2026Review
- Differing Patterns of Ionotropic Glutamate Receptor Subunit Gene Expression in Paraventricular Hypothalamic Nucleus Subregions following Angiotensin II Hypertension in Male Mice and Female Mice with Advanced Ovarian Failure.Neuroendocrinology · 2026Article
- Endocrine modulation of stimulant use: bidirectional interactions within the hypothalamic-pituitary-gonadal axis.Frontiers in behavioral neuroscience · 2026Review
- Preliminary study of sex-based neural responses and cognitive benefits of a 40 Hz rhythmic light intervention in mild cognitive impairment.Journal of Alzheimer's disease : JAD · 2025Article
- AMPA/kainate receptor activation within the prelimbic cortex is necessary for incubated cocaine-craving.Frontiers in psychiatry · 2025Article
- Antidepressant effects of activation of infralimbic cortex via upregulation of BDNF and β-catenin in an estradiol withdrawal model.Psychopharmacology · 2024Article
- Increased gene dosage of RFWD2 causes autistic-like behaviors and aberrant synaptic formation and function in mice.Molecular psychiatry · 2024Article
- The Impacts of Sex Differences and Sex Hormones on Fear Extinction.Current topics in behavioral neurosciences · 2023Article
- Sex Differences in Depression and Anxiety.Current topics in behavioral neurosciences · 2023Article
- Patchouli alcohol as a selective estrogen receptor β agonist ameliorates AD-like pathology of APP/PS1 model mice.Acta pharmacologica Sinica · 2022Article
- Sexually divergent cortical control of affective-autonomic integration.Psychoneuroendocrinology · 2021Article
- Sex and oestrogen receptor β have modest effects on gene expression in the mouse brain posterior cortex.Endocrinology, diabetes & metabolism · 2021Article
- Dynamic community detection reveals transient reorganization of functional brain networks across a female menstrual cycle.Network neuroscience (Cambridge, Mass.) · 2021Article
- Neuronal Representation of Locomotion During Motivated Behavior in the Mouse Anterior Cingulate Cortex.Frontiers in systems neuroscience · 2021Article
- The infralimbic cortex and mGlu5 mediate the effects of chronic intermittent ethanol exposure on fear learning and memory.Psychopharmacology · 2020Article
- The neurobiological basis of sex differences in learned fear and its inhibition.The European journal of neuroscience · 2020Review
- GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions.The Journal of clinical investigation · 2020Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Recent studies suggest that low endogenous estradiol might be a susceptibility factor for anxiety and trauma-related disorders in women. Consistently, fear extinction, a form of inhibitory learning critical for the management of anxiety symptoms, is positively correlated with endogenous estradiol levels. To understand the synaptic basis of the effect of endogenous estradiol on fear extinction, we studied glutamatergic transmission and plasticity in the infralimbic medial prefrontal cortex (IL-mPFC), a brain region crucial for the regulation of fear extinction. Diestrus mice (low estradiol) exhibited a higher basal glutamatergic transmission compared with proestrus mice (high estradiol). Synaptic plasticity was also regulated by endogenous estradiol, which favored synaptic potentiation in a GluN2B-dependent manner. Activation of estrogen receptor β (ERβ) but not ERα rescued synaptic potentiation in diestrus mice by enhancing GluN2B-mediated NMDA receptor transmission. Our results suggest that both endogenous estradiol and ERβ activation facilitate the ability of the IL-mPFC synapses to undergo potentiation, a mechanism necessary for the regulation of fear extinction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.