ArticlePflugers Archiv : European journal of physiology1988
Adenosine-5'-triphosphate-sensitive ion channels in neonatal rat cultured central neurones.
Article in Pflugers Archiv : European journal of physiology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 270 citations in OpenAlex.
- Current understanding of the contribution of lactate to the cardiovascular system and its therapeutic relevance.Frontiers in endocrinology · 2023Article
- Structural Insights Into the High Selectivity of the Anti-Diabetic Drug Mitiglinide.Frontiers in pharmacology · 2022Article
- Lactate is an energy substrate for rodent cortical neurons and enhances their firing activity.eLife · 2021Article
- Expression of truncated Kir6.2 promotes insertion of functionally inverted ATP-sensitive KScientific reports · 2021Article
- The Pharmacology of ATP-Sensitive KHandbook of experimental pharmacology · 2021Article
- Latest Insights into the Pathophysiology of Migraine: the ATP-Sensitive Potassium Channels.Current pain and headache reports · 2020Review
- Emerging Concepts in Brain Glucose Metabolic Functions: From Glucose Sensing to How the Sweet Taste of Glucose Regulates Its Own Metabolism in Astrocytes and Neurons.Neuromolecular medicine · 2018Review
- ATP sensitive potassium channel openers: A new class of ocular hypotensive agents.Experimental eye research · 2017Review
- Differential mechanisms of Cantú syndrome-associated gain of function mutations in the ABCC9 (SUR2) subunit of the KATP channel.The Journal of general physiology · 2015Article
- The Slow Oscillation in Cortical and Thalamic Networks: Mechanisms and Functions.Frontiers in neural circuits · 2015Review
- Ocular Hypotensive Effects of the ATP-Sensitive Potassium Channel Opener Cromakalim in Human and Murine Experimental Model Systems.PloS one · 2015Article
- The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system.British journal of pharmacology · 2014Review
- Neuroprotective role of ATP-sensitive potassium channels in cerebral ischemia.Acta pharmacologica Sinica · 2013Review
- Current understanding of K ATP channels in neonatal diseases: focus on insulin secretion disorders.Acta pharmacologica Sinica · 2011Review
- Glibenclamide increases post-fatigue tension in slow skeletal muscle fibers of the chicken.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2011Article
- The ATP-sensitive K(+)-channel (K(ATP)) controls early left-right patterning in Xenopus and chick embryos.Developmental biology · 2010Article
- Localization of ATP-sensitive K+ channel subunits in rat submandibular gland.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Article
- Glucose sensing neurons in the ventromedial hypothalamus.Sensors (Basel, Switzerland) · 2010Review
- Hyperinsulinaemic hypoglycaemia: biochemical basis and the importance of maintaining normoglycaemia during management.Archives of disease in childhood · 2007Review
- Cloning of a pore-forming subunit of ATP-sensitive potassium channel from Clonorchis sinensis.The Korean journal of parasitology · 2003Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ATP-sensitive channels were observed in isolated inside-out membrane patches from rat cultured central neurones. Two types of ATP-sensitive K+ channels were present in cortical neurones, one which had its open-state probability increased, the other its open-state probability decreased by application of ATP to the cytoplasmic membrane surface. Another, ATP-sensitive channel differing in ion conductance from all previously reported ATP-sensitive channels was also seen in patches from cortical neurones. This channel was nonselective with respect to Na+, K+ and Cl- ions and ATP produced a "flickery" type of block. The non-hydrolysable analogue, AMPPNP, did not mimic ATP and prevented ATP action. Preliminary experiments indicate that similar, but not, identical ATP-sensitive channels exist in cerebellar neurones.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.