Evidence map›Paper›PMID 24608187›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2014

Coffee intake and gastric cancer risk: the Singapore Chinese health study.

Cheryl E Ainslie-Waldman, Woon-Puay Koh, Aizhen Jin, Khay Guan Yeoh, Feng Zhu, Renwei Wang, Jian-Min Yuan, Lesley M Butler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 5 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 5 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Review
  7. Telomere length and risk of developing gastric adenocarcinoma: The Singapore Chinese Health Study.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2018
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Coffee Consumption and the Risk of Colorectal Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Cheryl E Ainslie-WaldmanAuthors' Affiliations: Division of Epidemiology and Community Health, University of Minnesota, Minneapolis; Department of Food Science and Nutrition, University of Minnesota, Saint Paul, Minnesota; Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania; Duke-NUS Graduate Medical School Singapore, Singapore; Saw Swee Hock School of Public Health and Department of Medicine, National University of Singapore, Singapore; National Registry of Diseases Office, Health Promotion Board; and Department of Gastroenterology and Hepatology, National University Health System, Singapore.
Woon-Puay Koh
Aizhen Jin
Khay Guan Yeoh
Feng Zhu
Renwei Wang
Jian-Min Yuan
Lesley M Butler
Duke-NUS Medical School · SGNational University of Singapore · SGUPMC Hillman Cancer Center · USNational University Health System · SG

Funding

Prospective studies of cancer etiology and prevention in Shanghai and SingaporeR01CA144034 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2010 to 2014
$7.0M
THE SINGAPORE COHORT STUDY OF DIET AND CANCERR01CA080205 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YUAN, JIAN-MIN · 1999 to 2009
$5.3M
Training Program in Nutrition and CancerT32CA132670 · NCI · UNIVERSITY OF MINNESOTA · PI ANDERSON, KRISTIN ELLEN · 2009 to 2013
$1.6M
COHORT STUDY OF DIET AND NASOPHYARYNGEAL CANCERR01CA055069 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YU, MIMI C. · 1992 to 1992
–
ENVIRONMENTAL EXPOSURES IN CANCER ETIOLOGYR35CA053890 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YU, MIMI C. · 1992 to 1998
–
NCI NIH HHS R01 CA055069NCI NIH HHS R01 CA080205NCI NIH HHS R01 CA144034NCI NIH HHS R35 CA053890NCI NIH HHS T32 CA132670NCI NIH HHS T32CA132670
6 · The paper itself

Abstract

backgroundDespite experimental evidence showing chemopreventive effects of coffee-related compounds on gastric carcinogenesis, epidemiologic studies generally do not support coffee-gastric cancer associations. Observational data are lacking among high-risk populations with sufficient regular coffee consumption.

methodsWe examined the association between caffeinated coffee intake and gastric cancer risk in a population-based cohort that enrolled 63,257 Chinese men and women ages 45 to 74 years between 1993 and 1998 in Singapore. Incident gastric cancer cases (n = 647) were identified after a mean follow-up of 14.7 years. Biomarkers of Helicobacter pylori (H. pylori) infection were measured in a subset of gastric cancer cases with blood collected before cancer diagnosis and their matched controls.

resultsIn the total cohort, daily versus nondaily coffee intake was associated with a statistically nonsignificant decrease in gastric cancer risk [HR = 0.85; 95% confidence interval (CI), 0.69-1.04]. In women, the inverse association strengthened and reached statistical significance (HR = 0.63; 95% CI, 0.46-0.87). In analyses restricted to never smokers and nondrinkers of alcohol, inverse associations strengthened in the total cohort (HR = 0.69; 95% CI, 0.52-0.91) and in women (HR = 0.52; 95% CI, 0.37-0.74). There was no coffee-gastric cancer risk association among men, regardless of smoking status or alcohol consumption. Similar results were observed in the nested case-control study after adjustment for H. pylori infection.

conclusionDaily coffee consumption may reduce the risk of gastric cancer in high-risk populations, especially among women. IMPACT: Research aimed at identifying the compounds in coffee that may protect against gastric carcinogenesis is warranted.

Indexed as

CoffeeAgedChinaCohort StudiesDrinking BehaviorFemaleHelicobacter InfectionsHelicobacter pyloriHumansMaleMiddle AgedRisk FactorsSingaporeStomach NeoplasmsCoffee

Identifiers

PMID24608187
PMCPMC4230822
OpenAlexW2109634783

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.