ArticleDatabase : the journal of biological databases and curation2014
NCG 4.0: the network of cancer genes in the era of massive mutational screenings of cancer genomes.
Article in Database : the journal of biological databases and curation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 67 citations in OpenAlex.
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- Identification of the miRNA signature associated with survival in patients with ovarian cancer.Aging · 2021Article
- Prognostic significance of LDL receptor-related protein 1B in patients with gastric cancer.Journal of molecular histology · 2021Article
- Pan-cancer detection of driver genes at the single-patient resolution.Genome medicine · 2021Article
- Germline copy number variations in BRCA1/2 negative families: Role in the molecular etiology of hereditary breast cancer in Tunisia.PloS one · 2021Article
- Rapid preliminary purity evaluation of tumor biopsies using deep learning approach.Computational and structural biotechnology journal · 2020Article
- Identifying driver genes involving gene dysregulated expression, tissue-specific expression and gene-gene network.BMC medical genomics · 2019Article
- A random walk-based method to identify driver genes by integrating the subcellular localization and variation frequency into bipartite graph.BMC bioinformatics · 2019Article
- Nuclear localization of LDL receptor-related protein 1B in mammary gland carcinogenesis.Journal of molecular medicine (Berlin, Germany) · 2019Article
- The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens.Genome biology · 2019Article
- Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer.Nature communications · 2017Article
- Perturbed human sub-networks by Fusobacterium nucleatum candidate virulence proteins.Microbiome · 2017Article
- A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes.Nature genetics · 2017Article
- GeneSCF: a real-time based functional enrichment tool with support for multiple organisms.BMC bioinformatics · 2016Article
- Practical aspects of NGS-based pathways analysis for personalized cancer science and medicine.Oncotarget · 2016Review
- HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes.Cancer research · 2016Article
- Characterization of long non-coding RNA-associated ceRNA network to reveal potential prognostic lncRNA biomarkers in human ovarian cancer.Oncotarget · 2016Article
- Relationship between microRNA genes incidence and cancer-associated genomic regions in canine tumors: a comprehensive bioinformatics study.Functional & integrative genomics · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NCG 4.0 is the latest update of the Network of Cancer Genes, a web-based repository of systems-level properties of cancer genes. In its current version, the database collects information on 537 known (i.e. experimentally supported) and 1463 candidate (i.e. inferred using statistical methods) cancer genes. Candidate cancer genes derive from the manual revision of 67 original publications describing the mutational screening of 3460 human exomes and genomes in 23 different cancer types. For all 2000 cancer genes, duplicability, evolutionary origin, expression, functional annotation, interaction network with other human proteins and with microRNAs are reported. In addition to providing a substantial update of cancer-related information, NCG 4.0 also introduces two new features. The first is the annotation of possible false-positive cancer drivers, defined as candidate cancer genes inferred from large-scale screenings whose association with cancer is likely to be spurious. The second is the description of the systems-level properties of 64 human microRNAs that are causally involved in cancer progression (oncomiRs). Owing to the manual revision of all information, NCG 4.0 constitutes a complete and reliable resource on human coding and non-coding genes whose deregulation drives cancer onset and/or progression. NCG 4.0 can also be downloaded as a free application for Android smart phones. Database URL: http://bio.ieo.eu/ncg/.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.