ArticleJournal of neural engineering2014
Selectivity of direct and network-mediated stimulation of the retinal ganglion cells with epi-, sub- and intraretinal electrodes.
Article in Journal of neural engineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
77 citing papers in PubMed, 151 citations in OpenAlex.
- Determinants of spatial resolution in retinal prostheses: understanding the gap between geometry and vision.Biomedical engineering letters · 2026Review
- Inhibitory Circuits Can Restore OFF Pathway Responses in Retinal Prostheses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Inkjet-Printed Rough Gold Microelectrode Arrays on Flexible Substrates for Neural Recording and Electrical Stimulation.ACS applied materials & interfaces · 2026Article
- Restoration of Sight with Electronic Retinal Prostheses.Annual review of vision science · 2025Review
- Electrical Stimulation of Cells: Drivers, Technology, and Effects.Chemical reviews · 2025Review
- Intraretinal Electrophysiology and Resistivity Profiles of WT and RCS Rat Retina.Sensors (Basel, Switzerland) · 2025Article
- Advances in Electrode Design and Physiological Considerations for Retinal Implants.Micromachines · 2025Review
- Focal stimulation of retinal ganglion cells using subretinal 3D microelectrodes with peripheral electrodes of opposite current.Biomedical engineering letters · 2024Article
- Comparison of modulation efficiency between normal and degenerated primate retina.Frontiers in cell and developmental biology · 2024Article
- A novel GCaMP6f-RCS rat model for studying electrical stimulation in the degenerated retina.Frontiers in cell and developmental biology · 2024Article
- Fabrication and Validation of Sub-Cellular Carbon Fiber Electrodes.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2024Article
- Multiple consecutive-biphasic pulse stimulation improves spatially localized firing of retinal ganglion cells in the degenerate retina.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023Article
- Losing, preserving, and restoring vision from neurodegeneration in the eye.Current biology : CB · 2023Review
- The Variation of Electrical Pulse Duration Elicits Reliable Network-Mediated Responses of Retinal Ganglion Cells in Normal, Not in Degenerate Primate Retinas.Bioengineering (Basel, Switzerland) · 2023Article
- Optimizing the fabrication of a 3D high-resolution implant for neural stimulation.Journal of biological engineering · 2023Article
- Electronic Retinal Prostheses.Cold Spring Harbor perspectives in medicine · 2023Review
- High amplitude pulses on the same charge condition efficiently elicit bipolar cell-mediated retinal ganglion cell responses in the degenerate retina.Biomedical engineering letters · 2023Article
- Bi-directional electrical recording and stimulation of the intact retina with a screen-printed soft probe: a feasibility study.Frontiers in neuroscience · 2023Article
- Implications of Neural Plasticity in Retinal Prosthesis.Investigative ophthalmology & visual science · 2022Article
- Pixel size limit of the PRIMA implants: from humans to rodents and back.Journal of neural engineering · 2022Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveIntra-retinal placement of stimulating electrodes can provide close and stable proximity to target neurons. We assessed improvement in stimulation thresholds and selectivity of the direct and network-mediated retinal stimulation with intraretinal electrodes, compared to epiretinal and subretinal placements. APPROACH: Stimulation thresholds of the retinal ganglion cells (RGCs) in wild-type rat retina were measured using the patch-clamp technique. Direct and network-mediated responses were discriminated using various synaptic blockers. MAIN
resultsThree types of RGC responses were identified: short latency (SL, τ < 5 ms) originating in RGCs, medium latency (ML, 3 < τ < 70 ms) originating in the inner nuclear layer and long latency (LL, τ > 40 ms) originating in photoreceptors. Cathodic epiretinal stimulation exhibited the lowest threshold for direct RGC response and the highest direct selectivity (network/direct thresholds ratio), exceeding a factor of 3 with pulse durations below 0.5 ms. For network-mediated stimulation, the lowest threshold was obtained with anodic pulses in OPL position, and its network selectivity (direct/network thresholds ratio) increased with pulse duration, exceeding a factor of 4 at 10 ms. Latency of all three types of responses decreased with increasing strength of the stimulus. SIGNIFICANCE: These results define the optimal range of pulse durations, pulse polarities and electrode placement for the retinal prostheses aiming at direct or network-mediated stimulation of RGCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.