ArticlePloS one2014
Investigation into the toxicity of traditional Uyghur medicine Quercus infectoria galls water extract.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Cytotoxic Activities of Some Cynipid (Hymenoptera: Cynipidae) Gall Extracts.Chemistry & biodiversity · 2026Article
- Cytotoxicity and Coagulation Effects of Methanolic Extracts ofJournal of experimental pharmacology · 2026Article
- Potent surface antimicrobial activity of hydrolyzable tannins from Aleppo oak galls.Scientific reports · 2025Article
- The anti-coronaviral activity of singular and mixed formulation of dill essential oil (Anethum graveolens L.) and tannic acid (Quercus infectoria).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- A Review of Medicinal Plants and Phytochemicals for the Management of Gout.Current rheumatology reviews · 2024Review
- Phytochemical Profiling and Biological Activities ofPlants (Basel, Switzerland) · 2023Review
- Antioxidants in Oak (Antioxidants (Basel, Switzerland) · 2023Review
- Safety assessment of theIranian journal of basic medical sciences · 2022Article
- Article
- An Evidence-Based Review of Medicinal Plants Used for the Treatment of Vaginitis byGalen medical journal · 2019Review
- The Pathogenicity and Transcriptome Analysis of Methicillin-ResistantEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Gallnuts: A Potential Treasure in Anticancer Drug Discovery.Evidence-based complementary and alternative medicine : eCAM · 2018Review
- Ethnopharmacological survey of medicinal plants practiced by traditional healers and herbalists for treatment of some urological diseases in the West Bank/Palestine.BMC complementary and alternative medicine · 2017Article
- Comparative Proteomic Analysis of Differential Proteins in Response to Aqueous Extract of Quercus infectoria Gall in Methicillin-Resistant Staphylococcus aureus.International journal of proteomics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveQuercus infectoria galls (QIG) is being widely used in Traditional Uyghur Medicine. To gather preclinical safety information for the aqueous extract of QIG, a toxicity study was performed.
methodsSubject animals were randomized, and divided into exposure and control groups. In the acute toxicity phase, three different doses--5, 7.5, and 10 g/kg, respectively--were administered via enema to imprinting control region (ICR) mice. An experiment using the maximum tolerance dose (MTD) i.e.10 g/kg was also performed. Data were gathered for 14 days, and study parameters were clinical signs, body weight, general behavior, adverse effects and mortality. At the day 14, major organs of the subjects were examined histologically. Chronic toxicity was also evaluated in Wistar rats for over 180 consecutive days. The rats were divided into three groups with different doses of 0.2 g/kg, 0.8 g/kg, and 2 g/kg, QIG. Furthermore, observations were carried out in rabbits to investigate if there were signs of irritation.
resultsIn comparison to control group, acute, chronic toxicity and mortality were not significantly increased in exposure group.
conclusionStudy result suggests that the aqueous extract of QIG is unlikely to have significant toxicity and that clinical trials may proceed safely.
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