ArticleJournal of neural engineering2014
Pre-frontal control of closed-loop limbic neurostimulation by rodents using a brain-computer interface.
Article in Journal of neural engineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Real-time closed-loop feedback system for mouse mesoscale cortical signal and movement control.eLife · 2026Article
- Modulation Steering Motion by Quantitative Electrical Stimulation in Pigeon Robots.Micromachines · 2024Article
- Closing the loop in psychiatric deep brain stimulation: physiology, psychometrics, and plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Somatosensory ECoG-based brain-machine interface with electrical stimulation on medial forebrain bundle.Biomedical engineering letters · 2023Article
- Mixed vine copula flows for flexible modeling of neural dependencies.Frontiers in neuroscience · 2022Article
- The Influence of Frequency Bands and Brain Region on ECoG-Based BMI Learning Performance.Sensors (Basel, Switzerland) · 2021Article
- Circumventing neural damage in a C. elegans chemosensory circuit using genetically engineered synapses.Cell systems · 2021Article
- Behavioral validation of a wireless low-power neurostimulation technology in a conditioned place preference task.Journal of neural engineering · 2019Article
- Closing the loop on impulsivity via nucleus accumbens delta-band activity in mice and man.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- High-frequency epidural stimulation across the respiratory cycle evokes phrenic short-term potentiation after incomplete cervical spinal cord injury.Journal of neurophysiology · 2017Article
- Closed-loop neuromodulation systems: next-generation treatments for psychiatric illness.International review of psychiatry (Abingdon, England) · 2017Review
- Operant conditioning of neural activity in freely behaving monkeys with intracranial reinforcement.Journal of neurophysiology · 2017Article
- Algorithmic design of a noise-resistant and efficient closed-loop deep brain stimulation system: A computational approach.PloS one · 2017Article
- Closing the Loop in Deep Brain Stimulation for Psychiatric Disorders: Lessons from Motor Neural Prosthetics.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- Affective Brain-Computer Interfaces As Enabling Technology for Responsive Psychiatric Stimulation.Brain computer interfaces (Abingdon, England) · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThere is great interest in closed-loop neurostimulators that sense and respond to a patient's brain state. Such systems may have value for neurological and psychiatric illnesses where symptoms have high intraday variability. Animal models of closed-loop stimulators would aid preclinical testing. We therefore sought to demonstrate that rodents can directly control a closed-loop limbic neurostimulator via a brain-computer interface (BCI). APPROACH: We trained rats to use an auditory BCI controlled by single units in prefrontal cortex (PFC). The BCI controlled electrical stimulation in the medial forebrain bundle, a limbic structure involved in reward-seeking. Rigorous offline analyses were performed to confirm volitional control of the neurostimulator. MAIN
resultsAll animals successfully learned to use the BCI and neurostimulator, with closed-loop control of this challenging task demonstrated at 80% of PFC recording locations. Analysis across sessions and animals confirmed statistically robust BCI control and specific, rapid modulation of PFC activity. SIGNIFICANCE: Our results provide a preliminary demonstration of a method for emotion-regulating closed-loop neurostimulation. They further suggest that activity in PFC can be used to control a BCI without pre-training on a predicate task. This offers the potential for BCI-based treatments in refractory neurological and mental illness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.