Evidence map›Paper›PMID 24608110›Full record

ArticlePloS one2014

Polymorphisms in the insulin-like growth factor axis are associated with gastrointestinal cancer.

Jennie Ong, Jody Salomon, Rene H M te Morsche, Hennie M J Roelofs, Ben J M Witteman, Polat Dura, Martin Lacko, Wilbert H M Peters

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Association study between growth hormone receptor (Journal of exercise rehabilitation · 2016
    Article
  9. Role of insulin-like growth factor-binding proteins in the pathophysiology and tumorigenesis of gastroesophageal cancers.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
    Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jennie OngDepartment of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
Jody SalomonDepartment of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
Rene H M te MorscheDepartment of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
Hennie M J RoelofsDepartment of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
Ben J M WittemanDepartment of Gastroenterology, Hospital Gelderse Vallei, Ede, the Netherlands.
Polat DuraDepartment of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
Martin LackoDepartment of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Center, Maastricht, the Netherlands.
Wilbert H M PetersDepartment of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
Radboud University Nijmegen · NLMaastricht University · NLZiekenhuis Gelderse Vallei · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNumerous factors influence the development of gastrointestinal (GI) cancer. The insulin-like growth factor (IGF) axis plays a role in embryonic and postnatal growth and tissue repair. Elevated levels of IGFs, low levels of IGF binding proteins (IGFBPs) and over-expression of IGF receptor (IGFR-I) were associated with several stages of cancer. Here, the prevalence of the single nucleotide polymorphisms (SNPs) rs6214 in the IGF type I (IGF-I) gene and rs6898743 in the growth hormone receptor (GHR) gene in patients with GI cancer and controls was studied. MATERIALS &

methodsIn this Dutch case-control study, DNA isolated from blood of 1,457 GI cancer patients; 438 patients with head and neck cancer (HNC), 475 with esophageal cancer (EC) and 544 with colorectal cancer (CRC) and 1,457 matched controls, was used to determine the rs6214 and rs6898743 genotypes by polymerase chain reaction. The association between these SNPs and GI cancer, HNC, esophageal adenocarcinoma (EAC), esophageal squamous-cell carcinoma (ESCC) and proximal or distal CRC was studied. Odds ratios (ORs) with 95% confidence interval (95% CI) were calculated via unconditional logistic regression.

resultsOverall for GI cancer, the ORs for SNPs rs6214 and rs6898743 were approximately 1.0 (p-value>0.05), using the most common genotypes GG as reference. An OR of 1.54 (95% CI, 1.05-2.27) was found for EC for genotype AA of rs6214. The ORs for EAC were 1.45 (95% CI, 1.04-2.01) and 1.71 (95% CI, 1.10-2.68), for genotypes GA and AA, respectively. Genotype GC of rs6898743 showed an OR of 0.47 (95% CI, 0.26-0.86) for ESCC.

conclusionThe A allele of SNP rs6214 in the IGF-I gene was associated with EAC, and with HNC in women. The GC genotype of rs6898743 in the GHR gene was negatively associated with ESCC.

Indexed as

Polymorphism, Single NucleotideAdenocarcinomaAgedAllelesCarcinoma, Squamous CellCase-Control StudiesColorectal NeoplasmsEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaFemaleGene ExpressionGene FrequencyGenotypeHead and Neck NeoplasmsHumansInsulin-Like Growth Factor IInsulin-Like Growth Factor IReceptors, Somatotropin

Identifiers

PMID24608110
PMCPMC3946608
OpenAlexW2115832526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.