ArticleJournal of medical ethics2014
Multiplex parenting: IVG and the generations to come.
Article in Journal of medical ethics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Ethical, Legal and Social Issues in Utilizing In Vitro Gametogenesis (IVG) and Stem Cell-Based Embryo Models (SCBEMs) for Human Reproduction in Singapore.Health care analysis : HCA : journal of health philosophy and policy · 2026Article
- Biological Parenthood in Relation to Future Artificial Reproductive Technologies : A Scoping Review of Definitions.Journal of bioethical inquiry · 2026Article
- Stem cell-derived gametes: what to expect when expecting their clinical introduction.Human reproduction (Oxford, England) · 2025Review
- Artificial Gametes and Human Reproduction in the 21st Century: An Ethical Analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- Anticipating in vitro gametogenesis: Hopes and concerns for IVG among diverse stakeholders.Stem cell reports · 2024Article
- Is there a valid ethical objection to the clinical use ofReproduction & fertility · 2021Review
- Drawing the line on in vitro gametogenesis.Bioethics · 2020Article
- Ethical Challenges of Germline Genetic Enhancement.Frontiers in genetics · 2019Review
- Lesbian motherhood and mitochondrial replacement techniques: reproductive freedom and genetic kinship.Journal of medical ethics · 2018Article
- "I am Your Mother and Your Father!" In Vitro Derived Gametes and the Ethics of Solo Reproduction.Health care analysis : HCA : journal of health philosophy and policy · 2017Article
- Resource Allocation, Treatment, Disclosure, and Mitochondrial Replacement Techniques.Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees · 2017Article
- Ethics of stem cell-derived gametes made in a dish: fertility for everyone?EMBO molecular medicine · 2017Article
- Article
- The (Re) Production of the Genetically Related Body in Law, Technology and Culture: Mitochondria Replacement Therapy.Health care analysis : HCA : journal of health philosophy and policy · 2016Article
- Creating human germ cells for unmet reproductive needs.Nature biotechnology · 2016Article
- Mitochondrial replacement techniques: egg donation, genealogy and eugenics.Monash bioethics review · 2016Review
- Oocyte cryopreservation beyond cancer: tools for ethical reflection.Journal of assisted reproduction and genetics · 2015Article
- Scientific Productivity on Research in Ethical Issues over the Past Half Century: A JoinPoint Regression Analysis.Tropical medicine and health · 2014Article
- Ethical aspects of creating human-nonhuman chimeras capable of human gamete production and human pregnancy.Monash bioethics reviewArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Recent breakthroughs in stem cell differentiation and reprogramming suggest that functional human gametes could soon be created in vitro. While the ethical debate on the uses of in vitro generated gametes (IVG) was originally constrained by the fact that they could be derived only from embryonic stem cell lines, the advent of somatic cell reprogramming, with the possibility to easily derive human induced pluripotent stem cells from any individual, affords now a major leap in the feasibility of IVG derivation and in the scope of their potential applications. In this paper we develop an ethical framework, rooted in recent scientific evidence, to support a robust experimental pipeline that could enable the first-in-human use of IVG. We then apply this framework to the following objectives: (1) a clarification of the genetic parenting options afforded by IVG, along with their ethical underpinnings; (2) a defence of the use of IVG to remedy infertility, broadening their scope to same-sex couples; (3) an assessment of the most far-reaching implications of IVG for multiplex parenting. These include, first, the liberation of parenting roles from the constraints of biological generations in vivo, allowing multiple individuals to engage in genetic parenting together, thus blurring the distinction between biological and social generations. Second, we discuss the conflation of IVG with sequencing technology and its implications for the possibility that prospective parents may choose among a hitherto unprecedented number of potential children. In view of these perspectives, we argue that, contrary to the exhausted paradigm according to which society lags behind science, IVG may represent instead a salient and most visible instance where biotechnological ingenuity could be used in pursuit of social experimentation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.