ArticleMolecular and cellular biology1988
Alternative RNA splicing that is spatially regulated: generation of transcripts from the Antennapedia gene of Drosophila melanogaster with different protein-coding regions.
Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Extracellular vesicles in the glioblastoma microenvironment: A diagnostic and therapeutic perspective.Molecular aspects of medicine · 2023Review
- Control of Hox transcription factor concentration and cell-to-cell variability by an auto-regulatory switch.Development (Cambridge, England) · 2019Article
- Regulated functional alternative splicing in Drosophila.Nucleic acids research · 2012Review
- Functional synthetic Antennapedia genes and the dual roles of YPWM motif and linker size in transcriptional activation and repression.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- cis-regulatory sequences responsible for alternative splicing of the Drosophila dopa decarboxylase gene.Molecular and cellular biology · 1994Article
- The Drosophila homeotic mutation Nasobemia (AntpNs) and its revertants: an analysis of mutational reversion.Genetics · 1994Article
- Tissue-specific alternative splicing of the Drosophila dopa decarboxylase gene is affected by heat shock.Molecular and cellular biology · 1993Article
- Oligonucleotide probes detect splicing variants in situ in Drosophila embryos.Nucleic acids research · 1992Article
- Structure of the gene encoding hepatocyte nuclear factor 1 (HNF1).Nucleic acids research · 1992Article
- Immunochemical dissection of the Ultrabithorax homeoprotein family in Drosophila melanogaster.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- The Drosophila Broad-Complex encodes a family of related proteins containing zinc fingers.Genetics · 1991Article
- Direct interaction of the Polycomb protein with Antennapedia regulatory sequences in polytene chromosomes of Drosophila melanogaster.The EMBO journal · 1991Article
- Molecular analysis of the bicoid gene from Drosophila pseudoobscura: identification of conserved domains within coding and noncoding regions of the bicoid mRNA.The EMBO journal · 1990Article
- Most of the homeobox-containing Xhox 36 transcripts in early Xenopus embryos cannot encode a homeodomain protein.Molecular and cellular biology · 1990Article
- Article
- Alternative processing of mRNAs encoding mammalian chromosomal high-mobility-group proteins HMG-I and HMG-Y.Molecular and cellular biology · 1989Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have shown previously that transcription of the Drosophila homeotic gene Antennapedia results in four major RNA species which differ in long 5'- and 3'-untranslated sequences. The protein-coding portion of these transcripts, however, is located in exons common to all. Using RNase protection assays and further cDNA clone isolation, we have now detected two alternative splicing events between exons of this region. These result in four RNA variations which, if translated, would encode a family of Antennapedia proteins. By analyzing transcripts from various developmental stages and isolated tissues, we show that alternative splicing is under strict temporal and spatial regulation. For example, while similar patterns of splicing were found for all wild-type thoracic imaginal disks examined, these differed distinctly from the patterns observed in neural tissues. Our results suggest that individual RNAs may be associated with different biological roles, and provide molecular evidence that the Antennapedia gene is involved in multiple functions.
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