Evidence map›Paper›PMID 24607365›Full record

Trial reportPreventive medicine2014

The therapeutic workplace to promote treatment engagement and drug abstinence in out-of-treatment injection drug users: a randomized controlled trial.

August F Holtyn, Mikhail N Koffarnus, Anthony DeFulio, Sigurdur O Sigurdsson, Eric C Strain, Robert P Schwartz, Jeannie-Marie S Leoutsakos, Kenneth Silverman

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Preventive medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01416584 (A Bridge to Treatment), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01416584 nacompletednot on this map

A Bridge to Treatment: The Therapeutic Workplace and Methadone Treatment

TypeinterventionalSponsorJohns Hopkins UniversityRan2008 to 2014Enrolled98ConditionsOpiate DependenceArmsmethadone contingency, Methadone & Abstinence Contingency
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  17. Reduction of classroom noise levels using group contingencies.Journal of applied behavior analysis · 2014
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

August F HoltynJohns Hopkins University School of Medicine, USA.
Mikhail N KoffarnusVirginia Tech Carilion Research Institute, USA.
Anthony DeFulioJohns Hopkins University School of Medicine, USA.
Sigurdur O SigurdssonJohns Hopkins University School of Medicine, USA; Florida Institute of Technology, USA.
Eric C StrainJohns Hopkins University School of Medicine, USA.
Robert P SchwartzFriends Research Institute, USA.
Jeannie-Marie S LeoutsakosJohns Hopkins University School of Medicine, USA.
Kenneth SilvermanJohns Hopkins University School of Medicine, USA. Electronic address: ksilverm@jhmi.edu.

Funding

HUMAN BEHAVIORAL PHARMACOLOGY OF SUBSTANCE ABUSET32DA007209 · NIDA · JOHNS HOPKINS UNIVERSITY · PI Eric C. Strain, Elise M Weerts · 1985 to 2026
$12.9M
A Bridge to Treatment for Out-of-Treatment Injection Heroin UsersR01DA023864 · NIDA · JOHNS HOPKINS UNIVERSITY · PI SILVERMAN, KENNETH · 2007 to 2011
$3.2M
Mentoring of Clinical Investigators in Patient Oriented ResearchK24DA023186 · NIDA · JOHNS HOPKINS UNIVERSITY · PI STRAIN, ERIC C. · 2007 to 2016
$1.8M
NIDA NIH HHS K24 DA023186NIDA NIH HHS K24DA023186NIDA NIH HHS R01 DA023864NIDA NIH HHS R01DA023864NIDA NIH HHS T32 DA007209NIDA NIH HHS T32DA07209
6 · The paper itself

Abstract

objectiveDetermine if employment-based reinforcement can increase methadone treatment engagement and drug abstinence in out-of-treatment injection drug users.

methodThis study was conducted from 2008 to 2012 in a therapeutic workplace in Baltimore, MD. After a 4-week induction, participants (N=98) could work and earn pay for 26 weeks and were randomly assigned to Work Reinforcement, Methadone & Work Reinforcement, and Abstinence, Methadone & Work Reinforcement conditions. Work Reinforcement participants had to work to earn pay. Methadone & Work Reinforcement and Abstinence, Methadone, & Work Reinforcement participants had to enroll in methadone treatment to work and maximize pay. Abstinence, Methadone, & Work Reinforcement participants had to provide opiate- and cocaine-negative urine samples to maximize pay.

resultsMost participants (92%) enrolled in methadone treatment during induction. Drug abstinence increased as a graded function of the addition of the methadone and abstinence contingencies. Abstinence, Methadone & Work Reinforcement participants provided significantly more urine samples negative for opiates (75% versus 54%) and cocaine (57% versus 32%) than Work Reinforcement participants. Methadone & Work Reinforcement participants provided significantly more cocaine-negative samples than Work Reinforcement participants (55% versus 32%).

conclusionThe therapeutic workplace can promote drug abstinence in out-of-treatment injection drug users. Clinical trial registration number: NCT01416584.

Indexed as

Analgesics, OpioidBaltimoreCocaine-Related DisordersEmploymentHealth BehaviorHospitals, TeachingHumansInterviews as TopicMethadoneMotivationOpioid-Related DisordersReinforcement, PsychologySubstance Abuse DetectionSubstance Abuse, IntravenousTreatment OutcomeWorkplaceAnalgesics, OpioidMethadoneCocaineContingency managementEmploymentFinancial incentivesInjection drug useMethadoneOpiateOut-of-treatment injection drug user

Identifiers

PMID24607365
PMCPMC4155024

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.