ArticleNeuron2014
The adaptive trade-off between detection and discrimination in cortical representations and behavior.
Article in Neuron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
- Deviance detection via competitive inhibition between local neocortical ensembles.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The neural code of perceptual inference.Molecular brain · 2026Review
- Alpha Modulation of Spiking Activity Across Multiple Brain Regions in Mice Performing a Tactile Selective Detection Task.The European journal of neuroscience · 2025Article
- Deviance detection via competitive inhibition between local neocortical ensembles.bioRxiv : the preprint server for biology · 2025Article
- A tactile discrimination task to study neuronal dynamics in freely-moving mice.Nature communications · 2025Article
- Corticothalamic modulation of somatosensory thalamic tactile processing.The Journal of physiology · 2025Article
- Multiple Distinct Timescales of Rapid Sensory Adaption in the Thalamocortical Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Sensory adaptation in the barrel cortex during active sensation in the behaving mouse.Scientific reports · 2024Article
- MULTIPLE DISTINCT TIMESCALES OF RAPID SENSORY ADAPATION IN THE THALAMOCORTICAL CIRCUIT.bioRxiv : the preprint server for biology · 2024Article
- Network influence determines the impact of cortical ensembles on stimulus detection.bioRxiv : the preprint server for biology · 2024Article
- Adapting and facilitating responses in mouse somatosensory cortex are dynamic and shaped by experience.Current biology : CB · 2024Article
- Coexistence of state, choice, and sensory integration coding in barrel cortex LII/III.Nature communications · 2024Article
- Adaptive decision-making depends on pupil-linked arousal in rats performing tactile discrimination tasks.Journal of neurophysiology · 2023Article
- Mechanisms of human dynamic object recognition revealed by sequential deep neural networks.PLoS computational biology · 2023Article
- Adaptive control of synaptic plasticity integrates micro- and macroscopic network function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Contribution of Interneuron Subtype-Specific GABAergic Signaling to Emergent Sensory Processing in Mouse Somatosensory Whisker Barrel Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Emerging experience-dependent dynamics in primary somatosensory cortex reflect behavioral adaptation.Nature communications · 2022Article
- Rapid Effects of Vagus Nerve Stimulation on Sensory Processing Through Activation of Neuromodulatory Systems.Frontiers in neuroscience · 2022Review
- Efficient and adaptive sensory codes.Nature neuroscience · 2021Article
- Rapid Cortical Adaptation and the Role of Thalamic Synchrony during Wakefulness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
It has long been posited that detectability of sensory inputs can be sacrificed in favor of improved discriminability and that sensory adaptation may mediate this trade-off. The extent to which this trade-off exists behaviorally and the complete picture of the underlying neural representations that likely subserve the phenomenon remain unclear. In the rodent vibrissa system, an ideal observer analysis of cortical activity measured using voltage-sensitive dye imaging in anesthetized animals was combined with behavioral detection and discrimination tasks, thalamic recordings from awake animals, and computational modeling to show that spatial discrimination performance was improved following adaptation, but at the expense of the ability to detect weak stimuli. Together, these results provide direct behavioral evidence for the trade-off between detectability and discriminability, that this trade-off can be modulated through bottom-up sensory adaptation, and that these effects correspond to important changes in thalamocortical coding properties.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.