Evidence map›Paper›PMID 24607007›Full record

ArticleJournal of biomechanics2014

Tension to passively cinch the mitral annulus through coronary sinus access: an ex vivo study in ovine model.

Shamik Bhattacharya, Thuy Pham, Zhaoming He, Wei Sun

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomechanics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Repairable ex vivo model of functional and degenerative mitral regurgitation.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2023
    Article
  2. Article
  3. Ex Vivo Model of Functional Mitral Regurgitation Using Deer Hearts.Journal of cardiovascular translational research · 2021
    Article
  4. Article
  5. Effects of Cinching Force on the Tricuspid Annulus: A Species Comparison.Journal of cardiovascular diseases & diagnosis · 2017
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Shamik BhattacharyaTissue Mechanics Laboratory Biomedical Engineering Program and Department of Mechanical Engineering University of Connecticut, Storrs, CT 06269, United States.
Thuy PhamTissue Mechanics Laboratory Biomedical Engineering Program and Department of Mechanical Engineering University of Connecticut, Storrs, CT 06269, United States.
Zhaoming HeDepartment of Mechanical Engineering Texas Tech University, Lubbock, TX 79409, United States.
Wei SunTissue Mechanics Laboratory Biomedical Engineering Program and Department of Mechanical Engineering University of Connecticut, Storrs, CT 06269, United States. Electronic address: wei.sun@bme.gatech.edu.
University of Connecticut · USTexas Tech University · US

Funding

Engineering Analysis of Minimally Invasive Mitral Valve RepairF31HL097722 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI PHAM, THUY M · 2009 to 2012
$125k
NHLBI NIH HHS F31 HL097722
6 · The paper itself

Abstract

introductionThe transcatheter mitral valve repair (TMVR) technique utilizes a stent to cinch a segment of the mitral annulus (MA) and reduces mitral regurgitation. The cinching mechanism results in reduction of the septal-lateral distance. However, the mechanism has not been characterized completely. In this study, a method was developed to quantify the relation between cinching tension and MA area in an ex vivo ovine model.

methodThe cinching tension was measured from a suture inserted within the coronary sinus (CS) vessel with one end tied to the distal end of the vessel and the other end exited to the CS ostium where it was attached to a force transducer on a linear stage. The cinching tension, MA area, septal-lateral (S-L) and commissure-commissure (C-C) diameters and leakage was simultaneously measured in normal and dilated condition, under a hydrostatic left ventricular pressure of 90 mm Hg.

resultsThe MA area was increased up to 22.8% after MA dilation. A mean tension of 2.1 ± 0.5 N reduced the MA area by 21.3 ± 5.6% and S-L diameter by 24.2 ± 5.3%. Thus, leakage was improved by 51.7 ± 16.2% following restoration of normal MA geometry.

conclusionThe cinching tension generated by the suture acts as a compensation force in MA reduction, implying the maximum tension needed to be generated by annuloplasty device to restore normal annular size. The relationship between cinching tension and the corresponding MA geometry will contribute to the development of future TMVR devices and understanding of myocardial contraction function.

Indexed as

AnimalsCoronary SinusHeartMitral ValveMitral Valve InsufficiencyMyocardial ContractionPressureSheepSheep, DomesticTransducersCinching tensionCoronary sinusFunctional mitral regurgitationMitral annulusTranscatheter mitral valve repair

Identifiers

PMID24607007
PMCPMC4033577
OpenAlexW2046446894

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.