ArticleActa neuropathologica communications2014
α4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets.
Article in Acta neuropathologica communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- α4 Integrin blockade impairs CD8+ T cell neuroimmune surveillance following SIV infection.The Journal of clinical investigation · 2026Article
- Physiological and pathological functions of TMEM106B in neurodegenerative diseases.Cellular and molecular life sciences : CMLS · 2024Review
- Identification of TMEM106B amyloid fibrils provides an updated view of TMEM106B biology in health and disease.Acta neuropathologica · 2022Review
- Natalizumab extended-interval dosing in multiple sclerosis to mitigate progressive multifocal leukoencephalopathy risk: initial study evidence and real-world experience.Journal of central nervous system disease · 2022Review
- Anti-αLβ2 antibodies reveal novel endocytotic cross-modulatory functionality.British journal of pharmacology · 2020Article
- IFN-γ is a therapeutic target in paraneoplastic cerebellar degeneration.JCI insight · 2019Article
- Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus.Journal of neuroinflammation · 2018Article
- Ena/VASP proteins regulate activated T-cell trafficking by promoting diapedesis during transendothelial migration.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- T cell responses in the central nervous system.Nature reviews. Immunology · 2017Review
- Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection.The Journal of clinical investigation · 2017Article
- Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection.The Journal of experimental medicine · 2016Article
- Migration of encephalitogenic CD8 T cells into the central nervous system is dependent on the α4β1-integrin.European journal of immunology · 2015Article
- VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells.The Journal of experimental medicine · 2014Article
- Combination PD-1 blockade and irradiation of brain metastasis induces an effective abscopal effect in melanoma.OncoimmunologyArticle
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionNatalizumab blocks α4-integrins and is a prototypic agent for a series of anti-inflammatory drugs that impair trafficking of immune cells into the CNS. However, modulation of the access of immune cells to the CNS is associated with impaired immune surveillance and detrimental viral infections of the CNS. Here, we explored the potency of cellular immune responses within the CNS to protect against viral encephalitis in mice with T cell conditional disruption of VLA-4 integrin (α4β1) expression.
resultsWhile VLA-4 expression in virus specific Th1 cells is non-redundant for their ability to access the CNS, α4-integrin deficient Th17 cells enter the CNS compartment and generate an inflammatory milieu upon intrathecal vaccinia virus (VV) infection. However, in contrast to Th1 cells that can adopt direct cytotoxic properties, Th17 cells fail to clear the virus due to insufficient Eomes induced perforin-1 expression.
conclusionThe quality of the intrathecal cellular antiviral response under conditions of impaired VLA-4 function jeopardizes host protection. Our functional in vivo data extend our mechanistic understanding of anti-viral immunity in the CNS and help to estimate the risk potential of upcoming therapeutic agents that target the trafficking of immune cells into distinct anatomical compartments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.