ArticleVirology2014
Elimination of A-type inclusion formation enhances cowpox virus replication in mice: implications for orthopoxvirus evolution.
Article in Virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Immunogenicity of poxvirus A16/G9 entry-fusion subcomplex and its restriction by A56/K2 protein informs vaccine design.Nature microbiology · 2026Article
- Viral genomic features predict Orthopoxvirus reservoir hosts.Communications biology · 2025Article
- Viral genomic features predictbioRxiv : the preprint server for biology · 2024Article
- Monkeypox virus genomic accordion strategies.Nature communications · 2024Article
- Cowpox Viruses: A Zoo Full of Viral Diversity and Lurking Threats.Biomolecules · 2023Review
- Article
- Identification, Isolation, and Characterization of an Ectromelia Virus New Strain from an Experimental Mouse.Virologica Sinica · 2021Article
- Crocodilepox Virus Evolutionary Genomics Supports Observed Poxvirus Infection Dynamics on Saltwater Crocodile (Viruses · 2019Article
- Article
- Polyglutamine Repeats in Viruses.Molecular neurobiology · 2019Review
- Review
- Novel Orthopoxvirus Infection in an Alaska Resident.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Out of the Reservoir: Phenotypic and Genotypic Characterization of a Novel Cowpox Virus Isolated from a Common Vole.Journal of virology · 2015Article
- Identification of nucleotide-level changes impacting gene content and genome evolution in orthopoxviruses.Journal of virology · 2014Article
- Effect of the ati Gene Deletion on the Pathogenicity and Immunogenicity of the Vaccinia Virus.Acta naturaeArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Some orthopoxviruses including cowpox virus embed virus particles in dense bodies, comprised of the A-type inclusion (ATI) protein, which may provide long-term environmental protection. This strategy could be beneficial if the host population is sparse or spread is inefficient or indirect. However, the formation of ATI may be neutral or disadvantageous for orthopoxviruses that rely on direct respiratory spread. Disrupted ATI open reading frames in orthopoxviruses such as variola virus, the agent of smallpox, and monkeypox virus suggests that loss of this feature provided positive selection. To test this hypothesis, we constructed cowpox virus mutants with deletion of the ATI gene or another gene required for embedding virions. The ATI deletion mutant caused greater weight loss and higher replication in the respiratory tract than control viruses, supporting our hypothesis. Deletion of the gene for embedding virions had a lesser effect, possibly due to known additional functions of the encoded protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.