Evidence map›Paper›PMID 24606679›Full record

ArticleVirology2014

Molecular characterization of the small nonstructural proteins of parvovirus Aleutian mink disease virus (AMDV) during infection.

Qinfeng Huang, Yong Luo, Fang Cheng, Sonja M Best, Marshall E Bloom, Jianming Qiu

Abstract read
In one paragraph

Article in Virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  6. Article
  7. Review
  8. AMDOPARVOVIRUS INFECTIONS ARE PREVALENT, PERSISTENT, AND GENETICALLY DIVERSE IN ZOO-HOUSED RED PANDAS (Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians · 2022
    Article
  9. Review
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Qinfeng HuangDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS 66160, United States.
Yong LuoDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS 66160, United States.
Fang ChengDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS 66160, United States.
Sonja M BestLaboratory of Virology, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT, United States.
Marshall E BloomLaboratory of Virology, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT, United States.
Jianming QiuDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS 66160, United States. Electronic address: jqiu@kumc.edu.
University of Kansas Medical Center · US

Funding

Virus-Host Interactions: Induction and Evasion of Host Innate ImmunityZIAAI001125 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BEST, SONJA · 2010 to 2025
$28.1M
Pathogenesis of Tick-Borne Flavivirus InfectionsZIAAI000940 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BLOOM, MARSHALL ELLIOTT · 2009 to 2025
$19.6M
Post-Transcriptional Regulation of Parvovirus Capsid Gene ExpressionR01AI070723 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI QIU, JIANMING · 2007 to 2017
$3.3M
Intramural NIH HHSNIAID NIH HHS R01 AI070723NIAID NIH HHS R01AI070723
6 · The paper itself

Abstract

Aleutian mink disease virus (AMDV) is the only member in genus Amdovirus of the family Parvoviridae. During AMDV infection, six species of viral transcripts are generated from one precursor mRNA through alternative splicing and alternative polyadenylation. In addition to the large non-structural protein NS1, two small non-structural proteins, NS2 and NS3, are putatively encoded (Qiu J, et al., 2006. J. Virol. 80 654-662). However, these two proteins have not been experimentally demonstrated during virus infection, and nothing is known about their function. Here, we studied the nonstructural protein expression profile of AMDV, and for the first time, confirmed expression of NS2 and NS3 during infection, and identified their intracellular localization. More importantly, we provided evidence that both NS2 and NS3 are necessary for AMDV replication.

Indexed as

Aleutian Mink DiseaseAleutian Mink Disease VirusAmino Acid SequenceAnimalsCell LineGene Expression Regulation, ViralMinkMolecular Sequence DataProtein TransportSequence AlignmentViral Nonstructural ProteinsViral Nonstructural ProteinsAleutian mink disease virusDNA replicationNon-structural proteinParvovirus

Identifiers

PMID24606679
PMCPMC3955004
OpenAlexW2169931582

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.