ArticleBiology of mood & anxiety disorders2014
Imaging the pathophysiology of major depressive disorder - from localist models to circuit-based analysis.
Article in Biology of mood & anxiety disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Neurocognitive deficits in depression: a systematic review of cognitive impairment in the acute and remitted state.European archives of psychiatry and clinical neuroscience · 2023Pooled it
- Functional connectivity of salience and affective networks among remitted depressed patients predicts episode recurrence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: evidence from a dopamine challenge study.Molecular psychiatry · 2022Trial
- Ketamine modulates fronto-striatal circuitry in depressed and healthy individuals.Molecular psychiatry · 2021Trial
- Neuropathophysiological changes associated with mirtazapine treatment response in major depressive disorder: insights into bottom-up dopaminergic pathways and prefrontal control networks.European archives of psychiatry and clinical neuroscience · 2026Article
- Brainstem Raphe Echogenicity and Insomnia in Type 2 Diabetes: An Exploratory Cross-Sectional Study.Life (Basel, Switzerland) · 2026Article
- Hypoactivation of the Ventromedial Frontal Cortex in Major Depressive Disorder: A Magnetoencephalography Study of the Reward Positivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Article
- Review
- Predictors of Treatment Outcome in Adolescent Depression.Current treatment options in psychiatry · 2021Article
- Depression Risk Is Associated With Weakened Synchrony Between the Amygdala and Experienced Emotion.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Inflammation and depressive phenotypes: evidence from medical records from over 12 000 patients and brain morphology.Psychological medicine · 2020Article
- Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress.Scientific reports · 2020Article
- Protein and gene markers of metabolic dysfunction and inflammation together associate with functional connectivity in reward and motor circuits in depression.Brain, behavior, and immunity · 2020Article
- Wiring the depressed brain: optogenetic and chemogenetic circuit interrogation in animal models of depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Fronto-limbic disconnection in patients with multiple sclerosis and depression.Multiple sclerosis (Houndmills, Basingstoke, England) · 2019Article
- Abnormal resting state activity of left middle occipital gyrus and its functional connectivity in female patients with major depressive disorder.BMC psychiatry · 2018Article
- Testing Causal Relationships Between Emotion Processing Circuitry and Behavior Using Noninvasive Brain Stimulation.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Article
- Reward Processing, Neuroeconomics, and Psychopathology.Annual review of clinical psychology · 2017Review
- Inflammation Effects on Motivation and Motor Activity: Role of Dopamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The neuroimaging literature of Major Depressive Disorder (MDD) has grown substantially over the last several decades, facilitating great advances in the identification of specific brain regions, neurotransmitter systems and networks associated with depressive illness. Despite this progress, fundamental questions remain about the pathophysiology and etiology of MDD. More importantly, this body of work has yet to directly influence clinical practice. It has long been a goal for the fields of clinical psychology and psychiatry to have a means of making objective diagnoses of mental disorders. Frustratingly little movement has been achieved on this front, however, and the 'gold-standard' of diagnostic validity and reliability remains expert consensus. In light of this challenge, the focus of the current review is to provide a critical summary of key findings from different neuroimaging approaches in MDD research, including structural, functional and neurochemical imaging studies. Following this summary, we discuss some of the current conceptual obstacles to better understanding the pathophysiology of depression, and conclude with recommendations for future neuroimaging research.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.