ArticleAmerican journal of respiratory and critical care medicine2014
Trajectories of lung function during childhood.
Article in American journal of respiratory and critical care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03229317 (Respiratory Outcome According to Early Maternal Vitamin D Status During Pregnancy in Children Aged 5 to 6 Years Old), which is not on this map. Cited by 67 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Respiratory Outcome According to Early Maternal Vitamin D Status During Pregnancy in Children Aged 5 to 6 Years Old
Who cites it
67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 180 citations in OpenAlex.
- Asthma, bronchial hyperresponsiveness, allergy and lung function development until early adulthood: A systematic literature review.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2021Pooled it
- A systematic review of the evidence of outdoor air pollution on asthma hospital visits in children and adolescents in South Asia - a call for data.Wellcome open research · 2021Pooled it
- Differential associations of allergic disease genetic variants with developmental profiles of eczema, wheeze and rhinitis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
- Pulmonary Function at Hospital Discharge in Preterm Infants Randomized to a Single Rescue Course of Antenatal Steroids.The Journal of pediatrics · 2017Trial
- Fueling the fire: metabolic dysfunction and senescence as drivers of lung aging and disease.Physiological reviews · 2026Review
- The protective effect of housing affordability on childhood asthma risk: a longitudinal fixed-effects analysis.American journal of epidemiology · 2026Article
- Joint modelling of wheeze and lung function from childhood to early adulthood: four population-based birth cohorts.EClinicalMedicine · 2026Article
- Clustering lung function and symptom profiles for asthma risk stratification.Scientific reports · 2025Article
- Early Onset Asthma, But Not Aeroallergen Sensitization, Is Associated With Lung Function Impairment in Young Adulthood-A Prospective Cohort Study.Clinical and translational allergy · 2025Article
- Patterns of Respiratory Symptoms and Asthma Diagnosis in School-Age Children: Three Birth Cohorts.Allergy · 2025Article
- Understanding and Managing Viral-Induced Wheezing in Children: The Role of Parental Knowledge.Journal of asthma and allergy · 2025Article
- Association between serum albumin and pulmonary function in adolescents: analyses of NHANES 2007-2012.BMC pulmonary medicine · 2024Article
- Relationships between lung function, allergy, and wheezing in urban children.The Journal of allergy and clinical immunology · 2024Article
- Pediatric asthma comorbidities: Global impact and unmet needs.The World Allergy Organization journal · 2024Review
- Obstructive and restrictive spirometry from school age to adulthood: three birth cohort studies.EClinicalMedicine · 2024Article
- Preschool children's asthma medication: parental knowledge, attitudes, practices, and adherence.Frontiers in pharmacology · 2024Article
- Caregivers' Perceptions, Needs, and Data Sharing Concerns in mHealth Research on Pediatric Asthma: Cross-Sectional Survey Study.JMIR pediatrics and parenting · 2023Article
- Asthma exacerbations are associated with a decline in lung function: a longitudinal population-based study.Thorax · 2023Article
- Evolution of Lung Function within Individuals: Clinical Insights and Data-driven Methods.American journal of respiratory and critical care medicine · 2023Article
- Plasticity of Individual Lung Function States from Childhood to Adulthood.American journal of respiratory and critical care medicine · 2023Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleDevelopmental patterns of lung function during childhood may have major implications for our understanding of the pathogenesis of respiratory disease throughout life.
objectivesTo explore longitudinal trajectories of lung function during childhood and factors associated with lung function decline.
methodsIn a population-based birth cohort, specific airway resistance (sRaw) was assessed at age 3 (n = 560), 5 (n = 829), 8 (n = 786), and 11 years (n = 644). Based on prospective data (questionnaires, skin tests, IgE), children were assigned to wheeze phenotypes (no wheezing, transient, late-onset, and persistent) and atopy phenotypes (no atopy, dust mite, non-dust mite, multiple early, and multiple late). We used longitudinal linear mixed models to determine predictors of change in sRaw over time. MEASUREMENTS AND MAIN
resultsContrary to the assumption that sRaw is independent of age and sex, boys had higher sRaw than girls (mean difference, 0.080; 95% confidence interval [CI], 0.049-0.111; P < 0.001) and a higher rate of increase over time. For girls, sRaw increased by 0.017 kPa ⋅ s(-1) per year (95% CI, 0.011-0.023). In boys this increase was significantly greater (P = 0.012; mean between-sex difference, 0.011 kPa ⋅ s(-1); 95% CI, 0.003-0.019). Children with persistent wheeze (but not other wheeze phenotypes) had a significantly greater rate of deterioration in sRaw over time compared with never wheezers (P = 0.009). Similarly, children with multiple early, but not other atopy phenotypes had significantly poorer lung function than those without atopy (mean difference, 0.116 kPa ⋅ s(-1); 95% CI, 0.065-0.168; P < 0.001). sRaw increased progressively with the increasing number of asthma exacerbations.
conclusionsChildren with persistent wheeze, frequent asthma exacerbations, and multiple early atopy have diminished lung function throughout childhood, and are at risk of a progressive loss of lung function from age 3 to 11 years. These effects are more marked in boys.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.