ArticleJournal of the American Chemical Society2014
Structure-activity relationships among antifungal nylon-3 polymers: identification of materials active against drug-resistant strains of Candida albicans.
Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 122 citations in OpenAlex.
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- Synergistic wall digestion and cuproptosis against fungal infections using lywallzyme-induced self-assembly of metal-phenolic nanoflowers.Nature communications · 2024Article
- Helicity-directed recognition of bacterial phospholipid via radially amphiphilic antimicrobial peptides.Science advances · 2024Article
- ApoE-functionalization of nanoparticles for targeted brain delivery-a feasible method for polyplexes?Drug delivery and translational research · 2024Article
- Recent developments in membrane targeting antifungal agents to mitigate antifungal resistance.RSC medicinal chemistry · 2023Review
- Polytrimethylenimines: Highly Potent Antibacterial Agents with Activity and Toxicity Modulated by the Polymer Molecular Weight.Biomacromolecules · 2023Article
- Switching from membrane disrupting to membrane crossing, an effective strategy in designing antibacterial polypeptide.Science advances · 2023Article
- Leaky membrane fusion: an ambivalent effect induced by antimicrobial polycations.Nanoscale advances · 2022Article
- Beyond nylon 6: polyamidesChemical Society reviews · 2022Review
- Self-Assembled Cationic Nanoparticles Combined with Curcumin against Multidrug-Resistant Bacteria.ACS omega · 2022Article
- Molecular Mapping of Antifungal Mechanisms Accessing Biomaterials and New Agents to Target Oral Candidiasis.International journal of molecular sciences · 2022Review
- Biomaterials for the Prevention of Oral Candidiasis Development.Pharmaceutics · 2021Review
- Cationic Homopolymers Inhibit Spore and Vegetative Cell Growth ofACS infectious diseases · 2021Article
- Antifungal Polymeric Materials and Nanocomposites.Frontiers in bioengineering and biotechnology · 2021Review
- Conformational preferences of cationic β-peptide in water studied by CCSD(T), MP2, and DFT methods.Heliyon · 2020Article
- Advances in Biomaterials for the Prevention and Disruption ofFrontiers in microbiology · 2020Review
- Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters.Nature communications · 2019Article
- The Impact of Nylon-3 Copolymer Composition on the Efficiency of siRNA Delivery to Glioblastoma Cells.Nanomaterials (Basel, Switzerland) · 2019Article
- Mechanistic Insights and Rational Design of a Versatile Surface with Cells/Bacteria Recognition Capability via Orientated Fusion Peptides.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Fungal infections are a major challenge to human health that is heightened by pathogen resistance to current therapeutic agents. Previously, we were inspired by host-defense peptides to develop nylon-3 polymers (poly-β-peptides) that are toxic toward the fungal pathogen Candida albicans but exert little effect on mammalian cells. Based on subsequent analysis of structure-activity relationships among antifungal nylon-3 polymers, we have now identified readily prepared cationic homopolymers active against strains of C. albicans that are resistant to the antifungal drugs fluconazole and amphotericin B. These nylon-3 polymers are nonhemolytic. In addition, we have identified cationic-hydrophobic copolymers that are highly active against a second fungal pathogen, Cryptococcus neoformans, and moderately active against a third pathogen, Aspergillus fumigatus.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.