ArticleThe Journal of clinical endocrinology and metabolism2014
Oxytocin secretion is related to measures of energy homeostasis in young amenorrheic athletes.
Article in The Journal of clinical endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Oxytocin reduces the functional connectivity between brain regions involved in eating behavior in men with overweight and obesity.International journal of obesity (2005) · 2020Trial
- How Does Physical Activity Modulate Hormone Responses?Biomolecules · 2024Review
- Understanding oxytocin in human physiology and pathophysiology: A path towards therapeutics.Comprehensive psychoneuroendocrinology · 2024Review
- Oxytocin and women's health in midlife.The Journal of endocrinology · 2024Review
- Review
- Follistatin Is Associated with Bone Mineral Density in Lean Adolescent Girls with Increased Physical Activity.Children (Basel, Switzerland) · 2023Article
- Associations of Circulating Irisin and Fibroblast Growth Factor-21 Levels with Measures of Energy Homeostasis in Highly Trained Adolescent Rhythmic Gymnasts.Journal of clinical medicine · 2022Article
- The female athlete triad: review of current literature.Current opinion in endocrinology, diabetes, and obesity · 2022Review
- Modulation of the thermosensory system by oxytocin.Frontiers in molecular neuroscience · 2022Review
- Progress and Challenges in the Biology of FNDC5 and Irisin.Endocrine reviews · 2021Review
- The New Frontier in Oxytocin Physiology: The Oxytonic Contraction.International journal of molecular sciences · 2020Review
- Metabolic Effects of Oxytocin.Endocrine reviews · 2020Review
- Oxytocin and Vasopressin Systems in Obesity and Metabolic Health: Mechanisms and Perspectives.Current obesity reports · 2019Review
- Oxytocin in metabolic homeostasis: implications for obesity and diabetes management.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2019Review
- Relationship of Circulating Irisin with Body Composition, Physical Activity, and Cardiovascular and Metabolic Disorders in the Pediatric Population.International journal of molecular sciences · 2018Review
- Plasma Oxytocin Concentration in Pre- and Postmenopausal Women: Its Relationship with Obesity, Body Composition and Metabolic Variables.Obesity facts · 2018Article
- The effects of oxytocin on eating behaviour and metabolism in humans.Nature reviews. Endocrinology · 2017Review
- Oxytocin and Its Relationship to Body Composition, Bone Mineral Density, and Hip Geometry Across the Weight Spectrum.The Journal of clinical endocrinology and metabolism · 2017Article
- Chronic CNS oxytocin signaling preferentially induces fat loss in high-fat diet-fed rats by enhancing satiety responses and increasing lipid utilization.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans.Physiology & behavior · 2015Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
contextOxytocin has been implicated in the modulation of energy metabolism in animals. Oxytocin knockout mice develop obesity without a change in food intake, suggesting that a lack of oxytocin may reduce metabolic rate. Furthermore, administration of oxytocin centrally reduces food intake in rats, an effect reversed by an oxytocin antagonist, implying that oxytocin may regulate appetite and energy intake. We have previously demonstrated that young female athletes (in a higher energy expenditure state than nonathletes) have low nocturnal oxytocin compared with nonathletes. Whether oxytocin is associated with measures of energy homeostasis in athletes is unknown.
objectiveWe hypothesized that oxytocin, a signal for energy availability, would be associated with other measures of energy homeostasis in young female athletes. DESIGN AND
settingWe performed a cross-sectional study of 45 females, aged 14-21 years [15 amenorrheic athletes (AA), 15 eumenorrheic athletes, and 15 nonathletes] of comparable body mass index.
methodsDual x-ray absorptiometry was performed to assess body composition. Indirect calorimetry was used to measure resting energy expenditure (REE). Fasting levels of oxytocin, energy homeostasis hormones irisin and fibroblast growth factor-21, and appetite-regulating hormone peptide YY were obtained.
resultsIn AA, oxytocin secretion was positively correlated with surrogate measures of energy availability, including weight (r = 0.65, P = .009) and body mass index (r = 0.61, P = .016). Furthermore, oxytocin was associated with REE (r = 0.80, P = .0003), independent of lean mass, and with irisin (r = 0.74, P = .002) and fibroblast growth factor-21 (r = 0.58, P = .024). In eumenorrheic athletes, oxytocin was associated with REE (r = 0.59, P = .021), independent of lean mass. In nonathletes, oxytocin secretion was not significantly associated with measures of energy homeostasis.
conclusionsIn AA, oxytocin secretion is associated with measures of energy availability and expenditure, suggesting that oxytocin may be involved in regulation of energy balance in energy deficient states. Further studies determining the role of oxytocin in appetite and energy homeostasis in athletes are warranted.
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