ArticleThe Journal of clinical endocrinology and metabolism2014
Luteal phase deficiency in regularly menstruating women: prevalence and overlap in identification based on clinical and biochemical diagnostic criteria.
Article in The Journal of clinical endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 93 citations in OpenAlex.
- Prospective evaluation of the impact of intermenstrual bleeding on natural fertility.Fertility and sterility · 2016Trial
- The Impact of Long COVID on the Female Reproductive System: A Narrative Review.International journal of molecular sciences · 2026Review
- Is there an effect of the start day of luteal phase support on pregnancy outcomes in natural vitrified-warmed blastocyst transfer?BMC pregnancy and childbirth · 2026Article
- Menstrual status and bone health in athletes from different sports - a retrospective analysis.BMC sports science, medicine & rehabilitation · 2026Article
- Monitoring Menstrual Health in Footballers: Considerations for Tracking Menstrual and Hormonal Contraceptive Cycles in the Field to Support Performance.Sports medicine (Auckland, N.Z.) · 2026Review
- Immunomodulatory Role of Natural Progesterone in Pregnancy: A Review.The journal of obstetrics and gynaecology research · 2026Review
- Changes in androgen profile over the menstrual cycle and hormonal contraceptive phases in physically active females.BMC women's health · 2026Article
- Menstrual Health in Servicewomen: The Menstrual Cycle, Menstrual Disturbances, and Occupational Consequences.Sports medicine - open · 2026Review
- Regulation of ovarian function in domestic animals: translational insights into human ovarian dynamics and dysfunction.Frontiers in endocrinology · 2026Review
- The Investigation of Vitamin D and Menstrual Cycles Trial (the inVitD Trial): A clinical trial of vitamin D supplementation on the hypothalamic-pituitary-ovarian axis.Contemporary clinical trials · 2026Article
- Accuracy of an Overnight Axillary-Temperature Sensor for Ovulation Detection: Validation in 194 Cycles.Sensors (Basel, Switzerland) · 2025Article
- Mixed pre-cooling improves thermal strain but not running performance in female endurance athletes exercising in the heat across the menstrual cycle.Temperature (Austin, Tex.) · 2025Article
- Level of Agreement Between a Modified, Three-Step Menstrual Cycle Tracking Method and a Female-Health Menstrual Cycle Tracking App.Women's health reports (New Rochelle, N.Y.) · 2025Article
- Progesterone decline threshold in predicting early pregnancy loss: a retrospective study.Frontiers in endocrinology · 2025Article
- Large animal models in gynecology: status and future perspectives.Frontiers in veterinary science · 2025Review
- Influence of Menstrual Phase and Symptoms on Sleep Before and After Matches for Professional Footballers.Scandinavian journal of medicine & science in sports · 2025Article
- Prospective 1-year assessment of within-woman variability of follicular and luteal phase lengths in healthy women prescreened to have normal menstrual cycle and luteal phase lengths.Human reproduction (Oxford, England) · 2024Observational
- Article
- The natural menstrual cycle revisited - can natural cycle be trusted.Journal of ovarian research · 2024Observational
- Studying reproductive and gynaecologic health as risk factors for chronic disease development.Paediatric and perinatal epidemiology · 2024Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
contextAlthough adequate luteal hormone production is essential for establishing pregnancy, luteal phase deficiency (LPD) is poorly characterized among eumenorrheic women.
objectiveWe assessed the prevalence and overlap of two established LPD diagnostic criteria: short luteal phase duration less than10 days (clinical LPD) and suboptimal luteal progesterone of 5 ng/mL or less (biochemical LPD) and their relationship with reproductive hormone concentrations. DESIGN, SETTING, AND
participantsWe conducted a prospective study in western New York (2005-2007) following 259 women, aged 18-44 years, for up to two menstrual cycles.
resultsAmong ovulatory cycles with recorded cycle lengths (n = 463), there were 41 cycles (8.9%) with clinical LPD, 39 cycles (8.4%) with biochemical LPD, and 20 cycles (4.3%) meeting both criteria. Recurrent clinical and biochemical LPD was observed in eight (3.4%) and five (2.1%) women, respectively. Clinical and biochemical LPD were each associated with lower follicular estradiol (both P ≤ .001) and luteal estradiol (P = .03 and P = .02, respectively) after adjusting for age, race, and percentage body fat. Clinical, but not biochemical, LPD was associated with lower LH and FSH across all phases of the cycle (P ≤ .001).
conclusionsClinical and biochemical LPD were evident among regularly menstruating women. Estradiol was lower in LPD cycles under either criterion, but LH and FSH were lower only in association with shortened luteal phase (ie, clinical LPD), indicating that clinical and biochemical LPD may reflect different underlying mechanisms. Identifying ovulation in combination with a well-timed luteal progesterone measurement may serve as a cost-effective and specific tool for LPD assessment by clinicians and researchers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.