ArticleFEMS microbiology letters2014
Minocycline resistance in an oral Streptococcus infantis isolate is encoded by tet(S) on a novel small, low copy number plasmid.
Article in FEMS microbiology letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- ISMicrobiology and molecular biology reviews : MMBR · 2024Review
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- Prevalence and Characteristics of Phenicol-Oxazolidinone Resistance Genes inInternational journal of molecular sciences · 2021Article
- Molecular Characteristics of ISmSphere · 2021Article
- ISmSphere · 2020Article
- Molecular characteristics of oxazolidinone resistance in enterococci from a multicenter study in China.BMC microbiology · 2019Article
- Characterization of a Linezolid- and Vancomycin-ResistantFrontiers in microbiology · 2019Article
- Article
- Analysis of two pheromone-responsive conjugative multiresistance plasmids carrying the novel mobileInfection and drug resistance · 2019Article
- Oral microbiome and health.AIMS microbiology · 2018Review
- Characterisation of the Chemical Composition and Structural Features of Novel Antimicrobial Nanoparticles.Nanomaterials (Basel, Switzerland) · 2017Article
- PCR-based detection of composite transposons and translocatable units from oral metagenomic DNA.FEMS microbiology letters · 2016Article
- The impact of horizontal gene transfer on the adaptive ability of the human oral microbiome.Frontiers in cellular and infection microbiology · 2014Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have determined the genetic basis of minocycline resistance in a strain of Streptococcus infantis isolated from a healthy human oral cavity. We demonstrate that tet(S), identical to tet(S) found on the enterococcal conjugative transposon Tn6000, is responsible for the observed resistance. The gene is located on a small, low copy number plasmid and is flanked by IS1216 elements. The tet(S) gene is capable of excising from the plasmid together with one of the IS1216 elements. The plasmid contains a putative toxin/antitoxin system related to relBE. Deletion of the toxin, relE, did not result in plasmid instability but did increase the fitness of the mutant compared to the wild-type strain.
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