Evidence map›Paper›PMID 24605806›Full record

ArticleJournal of internal medicine2014

Mild cognitive impairment: a concept in evolution.

R C Petersen, B Caracciolo, C Brayne, S Gauthier, V Jelic, L Fratiglioni

6 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of internal medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 782 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
782citing papers in PubMed, 18 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02987842 naunknown statusnot on this mapstarted 2016, after this paper: background citation

Neurofeedback as a Novel Treatment for Mild Cognitive Impairment & Early Alzheimer's

TypeinterventionalSponsorBeersheva Mental Health CenterRan2016 to 2017Enrolled30ConditionsMild Cognitive Impairment, Alzheimer DiseaseArmsTruScan Neurofeedback
NCT04311281 withdrawnnot on this mapstarted 2021, after this paper: background citation

[F-18] FDDNP-PET Clinical Protocol for Visualizing Brain Proteinopathies to Assist in the Diagnosis of Persons With Suspected Chronic Traumatic Encephalopathy and Alzheimer's Disease

TypeobservationalSponsorUniversity of California, Los AngelesRan2021 to 2021Enrolled0ConditionsSuspected Chronic Traumatic Encephalopathy (CTE) or Traumatic Encephalopathy Syndrome (TES), Suspected Alzheimer's Disease (AD)Arms[F-18]FDDNP-PET
NCT04705220 nacompletednot on this mapstarted 2022, after this paper: background citation

Effect of Nutritional Supplementation With Turmeric on the Cognitive Performance of Subjects With Metabolic Syndrome

TypeinterventionalSponsorIndena S.p.ARan2022 to 2025Enrolled85ConditionsMild Cognitive ImpairmentArmsMERIVA® Tablets, Placebo Tablets
NCT04788238 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Dual-Task Zumba Gold for Improving the Cognition of Community-Dwelling Older Adults With Mild Cognitive Impairment: A Pilot Randomized Controlled Trial

TypeinterventionalSponsorThe Hong Kong Polytechnic UniversityRan2021 to 2022Enrolled60ConditionsMild Cognitive ImpairmentArmsDual-Task Zumba Gold
NCT04955275 nacompletednot on this mapstarted 2021, after this paper: background citation

The Efficacy of a Remote Cognitive Remediation Therapy (CRT) Program on Parkinson's Disease

TypeinterventionalSponsorNew York Institute of TechnologyRan2021 to 2022Enrolled25ConditionsParkinson DiseaseArmsCognitive Remediation Therapy Program (BrainHQ)
NCT06252844 naunknown statusnot on this mapstarted 2024, after this paper: background citation

The Impact of 6-months of Resistance Training on Intrinsic Capacity, Cognition, and Brain/Circulating Biomarkers of Neuroplasticity and Neuroinflammation in Older Adults With Mild Cognitive Impairment: a Randomized Controlled Trial.

TypeinterventionalSponsorLithuanian Sports UniversityRan2024 to 2025Enrolled80ConditionsMild Cognitive Impairment, Older Adults at High Risk for MCIArmsResistance exercise training, Active control
3 · Its place in the literature

Who cites it

782 citing papers in PubMed, 18 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. A systematic review of interventions for persons living with dementia: The Geriatric ED Guidelines 2.0.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2026
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Social cognition in mild cognitive impairment and dementia: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Pooled it
  17. Pooled it
  18. Pooled it
  19. Effect of Multi-Modal Training in Patients With Mild Cognitive Impairment: A Randomized Controlled Pilot Trial.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Trial
  20. Trial

722 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

R C PetersenFrom the Mayo Alzheimer's Disease Research Center, Mayo Clinic College of Medicine, Rochester, MN, USA.
B Caracciolo
C Brayne
S Gauthier
V Jelic
L Fratiglioni

Funding

SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9M
NIA NIH HHS P50 AG016574NIA NIH HHS U01 AG006786
6 · The paper itself

Abstract

The construct of mild cognitive impairment (MCI) has evolved over the past 10 years since the publication of the new MCI definition at the Key Symposium in 2003, but the core criteria have remained unchanged. The construct has been extensively used worldwide, both in clinical and in research settings, to define the grey area between intact cognitive functioning and clinical dementia. A rich set of data regarding occurrence, risk factors and progression of MCI has been generated. Discrepancies between studies can be mostly explained by differences in the operationalization of the criteria, differences in the setting where the criteria have been applied, selection of subjects and length of follow-up in longitudinal studies. Major controversial issues that remain to be further explored are algorithmic versus clinical classification, reliability of clinical judgment, temporal changes in cognitive performances and predictivity of putative biomarkers. Some suggestions to further develop the MCI construct include the tailoring of the clinical criteria to specific populations and to specific contexts. The addition of biomarkers to the clinical phenotypes is promising but requires deeper investigation. Translation of findings from the specialty clinic to the population setting, although challenging, will enhance uniformity of outcomes. More longitudinal population-based studies on cognitive ageing and MCI need to be performed to clarify all these issues.

Indexed as

Alzheimer DiseaseCognitive DysfunctionMemory DisordersMental CompetencyAgedAgingBiomarkersCritical PathwaysDisease ProgressionFollow-Up StudiesHumansNeuropsychological TestsReproducibility of ResultsRisk FactorsBiomarkersAlzheimer's diseasedementiamemory impairmentmild cognitive impairment

Identifiers

PMID24605806
PMCPMC3967548

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.