ArticleGenes2013
Adenosine Triphosphate (ATP) Is a Candidate Signaling Molecule in the Mitochondria-to-Nucleus Retrograde Response Pathway.
Article in Genes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 45 citations in OpenAlex.
- Mitochondrial sirtuins, key regulators of aging.Life medicine · 2025Review
- ATP homeostasis and signaling in plants.Plant communications · 2024Review
- The yeast 14-3-3 proteins Bmh1 and Bmh2 regulate key signaling pathways.Frontiers in molecular biosciences · 2024Review
- COX17 restricts renal fibrosis development by maintaining mitochondrial copper homeostasis and restoring complex IV activity.Acta pharmacologica Sinica · 2023Article
- Mitochondrial Factors in the Cell Nucleus.International journal of molecular sciences · 2023Review
- Alleviating glucose repression and enhancing respiratory capacity to increase itaconic acid production.Synthetic and systems biotechnology · 2023Article
- Ubiquitin-Conjugating Enzymes Ubc1 and Ubc4 Mediate the Turnover of Hap4, a Master Regulator of Mitochondrial Biogenesis inMicroorganisms · 2022Article
- Nuclear-Mitochondrial Interactions.Biomolecules · 2022Review
- Overexpression of a single ORF can extend chronological lifespan in yeast if retrograde signaling and stress response are stimulated.Biogerontology · 2021Article
- The Regulatory Role of Key Metabolites in the Control of Cell Signaling.Biomolecules · 2020Review
- Mitochondria orchestrate proteostatic and metabolic stress responses.EMBO reports · 2019Review
- Conceptual Evolution of Cell Signaling.International journal of molecular sciences · 2019Review
- Increased expression of the P2X7 receptor in temporal lobe epilepsy: Animal models and clinical evidence.Molecular medicine reports · 2019Article
- Role of the ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control.Journal of clinical biochemistry and nutrition · 2019Review
- Mitochondria-cytosol-nucleus crosstalk: learning from Saccharomyces cerevisiae.FEMS yeast research · 2018Review
- The nuclear transcription factor Rtg1p functions as a cytosolic, post-transcriptional regulator in the methylotrophic yeastThe Journal of biological chemistry · 2018Article
- Adaptation to metabolic dysfunction during aging: Making the best of a bad situation.Experimental gerontology · 2018Review
- Penetrating cations induce pleiotropic drug resistance in yeast.Scientific reports · 2018Article
- Mitochondrial Energy Signaling and Its Role in the Low-Oxygen Stress Response of Plants.Plant physiology · 2018Review
- Structural and functional mapping of Rtg2p determinants involved in retrograde signaling and aging of Saccharomyces cerevisiae.PloS one · 2017Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Intracellular communication from the mitochondria to the nucleus is achieved via the retrograde response. In budding yeast, the retrograde response, also known as the RTG pathway, is regulated positively by Rtg1, Rtg2, Rtg3 and Grr1 and negatively by Mks1, Lst8 and two 14-3-3 proteins, Bmh1/2. Activation of retrograde signaling leads to activation of Rtg1/3, two basic helix-loop-helix leucine zipper transcription factors. Rtg1/3 activation requires Rtg2, a cytoplasmic protein with an N-terminal adenosine triphosphate (ATP) binding domain belonging to the actin/Hsp70/sugar kinase superfamily. The critical regulatory step of the retrograde response is the interaction between Rtg2 and Mks1. Rtg2 binds to and inactivates Mks1, allowing for activation of Rtg1/3 and the RTG pathway. When the pathway is inactive, Mks1 has dissociated from Rtg2 and bound to Bmh1/2, preventing activation of Rtg1/3. What signals association or disassociation of Mks1 and Rtg2 is unknown. Here, we show that ATP at physiological concentrations dissociates Mks1 from Rtg2 in a highly cooperative fashion. We report that ATP-mediated dissociation of Mks1 from Rtg2 is conserved in two other fungal species, K. lactis and K. waltii. Activation of Rtg1/3 upregulates expression of genes encoding enzymes catalyzing the first three reactions of the Krebs cycle, which is coupled to ATP synthesis through oxidative phosphorylation. Therefore, we propose that the retrograde response is an ATP homeostasis pathway coupling ATP production with ATP-mediated repression of the retrograde response by releasing Mks1 from Rtg2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.