Evidence map›Paper›PMID 24605173›Full record

ArticleBiomolecular concepts2012

Milk lipid secretion: recent biomolecular aspects.

James L McManaman

Abstract read
In one paragraph

Article in Biomolecular concepts, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Transporters and drug secretion into human breast milk.Expert opinion on drug metabolism & toxicology · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Liver X receptor-α activation enhances cholesterol secretion in lactating mammary epithelium.American journal of physiology. Endocrinology and metabolism · 2019
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Lipid transport in the lactating mammary gland.Journal of mammary gland biology and neoplasia · 2014
    Review
  14. Organellar Contacts of Milk Lipid Droplets.Contact (Thousand Oaks (Ventura County, Calif.))
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

James L McManamanDivision of Reproductive Sciences, Department of Obstetrics and Gynecology, Graduate Programs in Cell Biology, Stem Cells and Development, Molecular Biology and Reproductive Sciences, University of Colorado, School of Medicine, Aurora, CO 80045, USA.

Funding

The functional role of microRNAs in the normal mammary glandP01HD038129 · NICHD · UNIVERSITY OF COLORADO DENVER · PI ANDERSON, STEVEN M · 2000 to 2015
$15.2M
MECHANISMS OF MILK LIPID SECRETIONR01HD045965 · NICHD · UNIVERSITY OF COLORADO DENVER · PI MCMANAMAN, JAMES LEWIS · 2004 to 2013
$2.8M
North Carolina Collaborative PPRU NetworkU10HD045962 · NICHD · DUKE UNIVERSITY · PI BENJAMIN, DANIEL K. · 2004 to 2009
$2.1M
NICHD NIH HHS P01 HD038129NICHD NIH HHS R01 HD045965NICHD NIH HHS U10 HD045962
6 · The paper itself

Abstract

Neonates of most species depend on milk lipids for calories, fat-soluble vitamins, and bioactive lipid components for growth and development during the postnatal period. To meet neonatal nutrition and development needs, the mammary gland has evolved efficient mechanisms for synthesizing and secreting large quantities of lipid during lactation. Although the biochemical steps involved in milk lipid synthesis are understood, the identities of the genes mediating these steps and the molecular physiology of milk lipid production and secretion have only recently begun to be understood in detail through advances in mouse genetics, gene expression analysis, protein structural properties, and the cell biology of lipid metabolism. This review discusses emerging data about the molecular, cellular, and structural determinants of milk lipid synthesis and secretion within the context of physiological functions.

Indexed as

cellular mechanismsendoplasmic reticulummilk lipidmolecular modelsecretion

Identifiers

PMID24605173
PMCPMC3941198

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.