ArticleFrontiers in integrative neuroscience2014
Brainstem stimulation augments information integration in the cerebral cortex of desflurane-anesthetized rats.
Article in Frontiers in integrative neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Transnasal Ventral Brainstem Epidural Electrical Stimulation Enhances Consciousness in Anesthetized Sheep: A Feasibility Study.CNS neuroscience & therapeutics · 2026Article
- Microstimulation reveals anesthetic state-dependent effective connectivity of neurons in cerebral cortex.Frontiers in neuroscience · 2024Article
- Brain state identification and neuromodulation to promote recovery of consciousness.Brain communications · 2024Review
- Arousal system stimulation and anesthetic state alter visuoparietal connectivity.Frontiers in systems neuroscience · 2023Article
- Desflurane Anesthesia Alters Cortical Layer-specific Hierarchical Interactions in Rat Cerebral Cortex.Anesthesiology · 2020Article
- Level of Consciousness Is Dissociable from Electroencephalographic Measures of Cortical Connectivity, Slow Oscillations, and Complexity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The autonomic nervous system and the brainstem: A fundamental role or the background actors for consciousness generation? Hypothesis, evidence, and future directions for rehabilitation and theoretical approaches.Brain and behavior · 2020Review
- Repertoire of mesoscopic cortical activity is not reduced during anesthesia.Neuroscience · 2016Article
- Interactions between phasic alerting and consciousness in the fronto-striatal network.Scientific reports · 2016Article
- Critical Changes in Cortical Neuronal Interactions in Anesthetized and Awake Rats.Anesthesiology · 2015Article
- On the brain-imaging markers of neural correlates of consciousness.Frontiers in psychology · 2015Article
- It is time to combine the two main traditions in the research on the neural correlates of consciousness: C = L × D.Frontiers in psychology · 2014Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
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Abstract
States of consciousness have been associated with information integration in the brain as modulated by anesthesia and the ascending arousal system. The present study was designed to test the hypothesis that electrical stimulation of the oral part of the pontine reticular nucleus (PnO) can augment information integration in the cerebral cortex of anesthetized rats. Extracellular unit activity and local field potentials were recorded in freely moving animals from parietal association (PtA) and secondary visual (V2) cortices via chronically implanted microwire arrays at three levels of anesthesia produced by desflurane: 3.5, 4.5, and 6.0% (where 4.5% corresponds to that critical for the loss of consciousness). Information integration was characterized by integration (multiinformation) and interaction entropy, estimated from the statistical distribution of coincident spike patterns. PnO stimulation elicited electrocortical activation as indicated by the reductions in δ- and θ-band powers at the intermediate level of anesthesia. PnO stimulation augmented integration from 1.13 ± 0.03 to 6.12 ± 1.98 × 10(3) bits and interaction entropy from 0.44 ± 0.11 to 2.18 ± 0.72 × 10(3) bits; these changes were most consistent in the PtA at all desflurane concentrations. Stimulation of the retina with discrete light flashes after PnO stimulation elicited an additional 166 ± 25 and 92 ± 12% increase in interaction entropy in V2 during light and intermediate levels. The results suggest that the PnO may modulate spontaneous ongoing and sensory stimulus-related cortical information integration under anesthesia.
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