Evidence map›Paper›PMID 24605026›Full record

SynthesisWorld journal of gastroenterology2014

Systematic review of novel ablative methods in locally advanced pancreatic cancer.

Margaret G Keane, Konstantinos Bramis, Stephen P Pereira, Giuseppe K Fusai

Registry-linked trialAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03435770 (Evaluation of Safety and Feasibility of Endoscopic Ultrasound), which is not on this map. Cited by 64 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03435770 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Evaluation of Safety and Feasibility of Endoscopic Ultrasound (EUS)-Guided Radiofrequency Ablation (RFA) for Solid Pancreatic Neoplasms

TypeinterventionalSponsorSingapore General HospitalRan2018 to 2019Enrolled10ConditionsPancreatic Cancer, Pancreatic Neoplasms, Pancreatic Adenocarcinoma, Pancreatic Neuroendocrine TumorArmsEUSRA RFA needle
3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
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  8. Article
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  13. High-intensity focused ultrasound therapy for pancreatic cancer.Journal of medical ultrasonics (2001) · 2022
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Tailor-Made Nanomaterials for Diagnosis and Therapy of Pancreatic Ductal Adenocarcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Margaret G KeaneMargaret G Keane, Stephen P Pereira, Institute for Liver and Digestive Health, University College London, Royal Free Campus, London NW3 2PF, United Kingdom.
Konstantinos BramisMargaret G Keane, Stephen P Pereira, Institute for Liver and Digestive Health, University College London, Royal Free Campus, London NW3 2PF, United Kingdom.
Stephen P PereiraMargaret G Keane, Stephen P Pereira, Institute for Liver and Digestive Health, University College London, Royal Free Campus, London NW3 2PF, United Kingdom.
Giuseppe K FusaiMargaret G Keane, Stephen P Pereira, Institute for Liver and Digestive Health, University College London, Royal Free Campus, London NW3 2PF, United Kingdom.

Funding

Small Molecule Enhancers of Photodynamic Therapy for Skin CancerP01CA084203 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Bryan Quilty Spring · 2001 to 2026
$27.9M
Department of HealthNCI NIH HHS P01 CA084203NCI NIH HHS P01CA84203
6 · The paper itself

Abstract

Unresectable locally advanced pancreatic cancer with or without metastatic disease is associated with a very poor prognosis. Current standard therapy is limited to chemotherapy or chemoradiotherapy. Few regimens have been shown to have a substantial survival advantage and novel treatment strategies are urgently needed. Thermal and laser based ablative techniques are widely used in many solid organ malignancies. Initial studies in the pancreas were associated with significant morbidity and mortality, which limited widespread adoption. Modifications to the various applications, in particular combining the techniques with high quality imaging such as computed tomography and intraoperative or endoscopic ultrasound has enabled real time treatment monitoring and significant improvements in safety. We conducted a systematic review of the literature up to October 2013. Initial studies suggest that ablative therapies may confer an additional survival benefit over best supportive care but randomised studies are required to validate these findings.

Indexed as

Ablation TechniquesCarcinoma, Pancreatic DuctalCatheter AblationCryosurgeryElectroporationHigh-Intensity Focused Ultrasound AblationHumansLaser TherapyMicrowavesPancreatic NeoplasmsPrecancerous ConditionsTreatment OutcomeCryoablationHigh frequency focused ultrasoundIrreversible electroporationMicrowave ablationPancreatic cancerPhotodynamic therapyRadiofrequency ablation

Identifiers

PMID24605026
PMCPMC3942832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.