ArticleAngewandte Chemie (International ed. in English)2014
Regio- and stereoselective 1,2-dihydropyridine alkylation/addition sequence for the synthesis of piperidines with quaternary centers.
Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- One-pot reaction of 3-vinylchromones, aromatic aldehydes, and ammonium acetate: an efficient approach to highly functionalized 1,6-dihydropyridine derivatives.RSC advances · 2025Article
- Substituted Dihydropyridine Synthesis by Dearomatization of Pyridines.Angewandte Chemie (International ed. in English) · 2021Article
- Rhodium-Catalyzed C-H Alkenylation/Electrocyclization Cascade Provides Dihydropyridines That Serve as Versatile Intermediates to Diverse Nitrogen Heterocycles.Accounts of chemical research · 2021Review
- Controlled partial transfer hydrogenation of quinolines by cobalt-amido cooperative catalysis.Nature communications · 2020Article
- Reactions of Allylmagnesium Reagents with Carbonyl Compounds and Compounds with C═N Double Bonds: Their Diastereoselectivities Generally Cannot Be Analyzed Using the Felkin-Anh and Chelation-Control Models.Chemical reviews · 2020Review
- π-Facial Selectivities in Hydride Reductions of Hindered Endocyclic Iminium Ions.The Journal of organic chemistry · 2019Article
- New Regio- and Stereoselective Cascades via Unstabilized Azomethine Ylide Cycloadditions for the Synthesis of Highly Substituted Tropane and Indolizidine Frameworks.Journal of the American Chemical Society · 2016Article
- Iridium-catalyzed selective 1,2-hydrosilylation of N-heterocycles.Chemical science · 2016Article
- Synthesis of Ethers via Reaction of Carbanions and Monoperoxyacetals.The Journal of organic chemistry · 2015Article
- Synthesis of ent-ketorfanol via a C-H alkenylation/torquoselective 6π electrocyclization cascade.Angewandte Chemie (International ed. in English) · 2015Article
- Catalytic Kinetic Resolution of Disubstituted Piperidines by Enantioselective Acylation: Synthetic Utility and Mechanistic Insights.Journal of the American Chemical Society · 2015Article
- Regio- and Diastereoselective Synthesis of Highly Substituted, Oxygenated Piperidines from Tetrahydropyridines.The Journal of organic chemistry · 2015Article
- Rh(I)-Catalyzed Cycloisomerization of 1,6-Enynes.Synlett : accounts and rapid communications in synthetic organic chemistry · 2015Article
- Atom-efficient regioselective 1,2-dearomatization of functionalized pyridines by an earth-abundant organolanthanide catalyst.Nature chemistry · 2014Article
- Preparative Synthesis of Highly Substituted Tetrahydropyridines via a Rh(I)-Catalyzed C-H Functionalization Sequence.Organic process research & development · 2014Review
- Convergent Synthesis of Diverse Tetrahydropyridines via Rh(I)-Catalyzed C-H Functionalization Sequences.Organic process research & development · 2014Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The first example of C alkylation of 1,2-dihydropyridines with alkyl triflates and Michael acceptors was developed to introduce quaternary carbon centers with high regio- and diastereoselectivity. Hydride or carbon nucleophile addition to the resultant iminium ion also proceeded with high diastereoselectivity. Carbon nucleophile addition results in an unprecedented level of substitution to provide piperidine rings with adjacent tetrasubstituted carbon atoms.
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