ArticleChemphyschem : a European journal of chemical physics and physical chemistry2014
Two-photon-induced fluorescence of isomorphic nucleobase analogs.
Article in Chemphyschem : a European journal of chemical physics and physical chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 18 citations in OpenAlex.
- Isomorphic Fluorescent Nucleosides.Accounts of chemical research · 2024Article
- Covalent labeling of nucleic acids.Chemical Society reviews · 2020Review
- Single-Molecule Detection of a Fluorescent Nucleobase Analogue via Multiphoton Excitation.The journal of physical chemistry letters · 2019Article
- Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue.Chemical science · 2018Article
- Enzymatic incorporation and utilization of an emissive 6-azauridine.Organic & biomolecular chemistry · 2017Article
- Isomorphic emissive GTP surrogate facilitates initiation and elongation of in vitro transcription reactions.Journal of the American Chemical Society · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Five isomorphic fluorescent uridine mimics have been subjected to two-photon (2P) excitation analysis to investigate their potential applicability as non-perturbing probes for the single-molecule detection of nucleic acids. We find that small structural differences can cause major changes in the 2P excitation probability, with the 2P cross sections varying by over one order of magnitude. Two of the probes, both thiophene-modified uridine analogs, have the highest 2P cross sections (3.8 GM and 7.6 GM) reported for nucleobase analogs, using a conventional Ti:sapphire laser for excitation at 690 nm; they also have the lowest emission quantum yields. In contrast, the analogs with the highest reported quantum yields have the lowest 2P cross sections. The structure-photophysical property relationship presented here is a first step towards the rational design of emissive nucleobase analogs with controlled 2P characteristics. The results demonstrate the potential for major improvements through judicious structural modifications.
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Registered trials
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